RCC2 [The Human Chemical-Genetic Interaction Map Project]

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======= RCC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RCC2
  * **<color #00a2e8>Official Name</color>**: regulator of chromosome condensation 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55920|55920]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P258|Q9P258]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RCC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RCC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609587|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a guanine exchange factor that is active on RalA, a small GTPase. The encoded protein and RalA are both essential for proper kinetochore-microtubule function in early mitosis. This protein has been shown to be a biomarker for colorectal cancer. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1. {ECO:0000269|PubMed:12919680}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RCC1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chromosome, centromeric core domain|
|chromosome passenger complex localization to kinetochore|
|positive regulation of attachment of spindle microtubules to kinetochore|
|regulation of attachment of spindle microtubules to kinetochore|
|negative regulation of substrate adhesion-dependent cell spreading|
|protein localization to kinetochore|
|mitotic spindle midzone|
|protein localization to chromosome, centromeric region|
|negative regulation of focal adhesion assembly|
|negative regulation of adherens junction organization|
|small GTPase binding|
|negative regulation of cell junction assembly|
|cellular protein-containing complex localization|
|positive regulation of G2/M transition of mitotic cell cycle|
|focal adhesion assembly|
|cell-substrate adherens junction assembly|
|positive regulation of chromosome segregation|
|regulation of ruffle assembly|
|positive regulation of cell cycle G2/M phase transition|
|regulation of fibroblast migration|
|adherens junction assembly|
|negative regulation of cell-matrix adhesion|
|cell-substrate junction assembly|
|negative regulation of GTPase activity|
|regulation of substrate adhesion-dependent cell spreading|
|Rac GTPase binding|
|regulation of cell-substrate junction assembly|
|regulation of focal adhesion assembly|
|negative regulation of cell-substrate adhesion|
|protein localization to chromosome|
|regulation of adherens junction organization|
|positive regulation of mitotic cell cycle phase transition|
|adherens junction organization|
|regulation of cell junction assembly|
|positive regulation of cell cycle phase transition|
|integrin-mediated signaling pathway|
|activation of GTPase activity|
|negative regulation of cell morphogenesis involved in differentiation|
|regulation of chromosome segregation|
|guanyl-nucleotide exchange factor activity|
|regulation of cell-matrix adhesion|
|cell-matrix adhesion|
|positive regulation of mitotic cell cycle|
|early endosome membrane|
|midbody|
|cell junction assembly|
|cell-substrate adhesion|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of cell cycle G2/M phase transition|
|regulation of cell-substrate adhesion|
|cell junction organization|
|microtubule binding|
|protein domain specific binding|
|protein-containing complex localization|
|negative regulation of cell adhesion|
|positive regulation of cell cycle process|
|regulation of cell morphogenesis involved in differentiation|
|microtubule|
|negative regulation of cell development|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|positive regulation of GTPase activity|
|regulation of cell cycle phase transition|
|negative regulation of hydrolase activity|
|protein kinase binding|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|cell division|
|regulation of mitotic cell cycle|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|protein localization to organelle|
|regulation of cell cycle process|
|positive regulation of hydrolase activity|
|negative regulation of catalytic activity|
|regulation of cell migration|
|nucleolus|
|regulation of cell motility|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|negative regulation of molecular function|
|regulation of cell cycle|
|regulation of hydrolase activity|
|cell cycle|
|RNA binding|
|positive regulation of catalytic activity|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of molecular function|
|regulation of cell differentiation|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-2.65|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.27|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.12|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.11|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.97|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.75|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.7|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.73|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.79|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.85|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.86|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.11|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.11|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.11|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7551
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RCC2 Expression in NALM6 Cells: 8.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>