RCHY1 [The Human Chemical-Genetic Interaction Map Project]

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======= RCHY1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RCHY1
  * **<color #00a2e8>Official Name</color>**: ring finger and CHY zinc finger domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25898|25898]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96PM5|Q96PM5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RCHY1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RCHY1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607680|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-CHY|
|zf-C3HC4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|error-free translesion synthesis|
|translesion synthesis|
|DNA synthesis involved in DNA repair|
|postreplication repair|
|p53 binding|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of proteasomal protein catabolic process|
|ubiquitin ligase complex|
|DNA biosynthetic process|
|positive regulation of protein ubiquitination|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|positive regulation of protein modification by small protein conjugation or removal|
|positive regulation of cellular protein catabolic process|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of proteasomal protein catabolic process|
|regulation of protein ubiquitination|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|regulation of protein modification by small protein conjugation or removal|
|ubiquitin-protein transferase activity|
|regulation of cellular protein catabolic process|
|signaling receptor binding|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|nuclear speck|
|positive regulation of catabolic process|
|DNA repair|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|regulation of proteolysis|
|DNA metabolic process|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|regulation of cellular catabolic process|
|zinc ion binding|
|protein homodimerization activity|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of protein modification process|
|proteolysis|
|organic cyclic compound biosynthetic process|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp115|A-366 10μM R03 exp115]]|-1.88|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-1.87|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.84|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13611
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RCHY1 Expression in NALM6 Cells: 4.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>