RCOR1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= RCOR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RCOR1
  * **<color #00a2e8>Official Name</color>**: REST corepressor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23186|23186]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UKL0|Q9UKL0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RCOR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RCOR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607675|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. {ECO:0000269|PubMed:11171972, ECO:0000269|PubMed:11516394, ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:12493763, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16140033}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ELM2|
|Myb DNA-binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA repair complex|
|histone H4 deacetylation|
|histone deacetylation|
|protein deacetylation|
|transcriptional repressor complex|
|protein deacylation|
|macromolecule deacylation|
|transcription factor complex|
|transcription regulatory region DNA binding|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|blood coagulation|
|coagulation|
|hemostasis|
|transcription factor binding|
|histone modification|
|covalent chromatin modification|
|wound healing|
|regulation of body fluid levels|
|response to wounding|
|DNA-binding transcription factor activity|
|chromatin organization|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|negative regulation of transcription by RNA polymerase II|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-2.35|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-2.28|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.1|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.06|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.95|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-1.86|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.76|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.75|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.73|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.73|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.76|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.77|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.8|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.83|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.93|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.06|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|2.1|
|[[:results:exp224|CB-839 10μM R05 exp224]]|2.76|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.78|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|3.1|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hdac2|HDAC2]]|0.453|
|[[:human genes:k:kdm1a|KDM1A]]|0.436|
|[[:human genes:m:mta2|MTA2]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 27/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|9/28|
|bone|0/25|
|breast|3/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|1/14|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|2/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5116
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RCOR1 Expression in NALM6 Cells: 6.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>