REC8 [The Human Chemical-Genetic Interaction Map Project]

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======= REC8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: REC8
  * **<color #00a2e8>Official Name</color>**: REC8 meiotic recombination protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9985|9985]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95072|O95072]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=REC8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20REC8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608193|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rad21 Rec8|
|Rad21 Rec8 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear meiotic cohesin complex|
|meiotic cohesin complex|
|condensed nuclear chromosome kinetochore|
|seminiferous tubule development|
|lateral element|
|male germ cell nucleus|
|synaptonemal complex assembly|
|oocyte maturation|
|synaptonemal complex organization|
|male meiosis I|
|oocyte development|
|oocyte differentiation|
|synapsis|
|male meiotic nuclear division|
|sister chromatid cohesion|
|reciprocal meiotic recombination|
|homologous recombination|
|homologous chromosome segregation|
|chromosome organization involved in meiotic cell cycle|
|oogenesis|
|meiotic chromosome segregation|
|double-strand break repair via homologous recombination|
|recombinational repair|
|meiosis I|
|meiosis I cell cycle process|
|female gamete generation|
|male gonad development|
|anatomical structure maturation|
|development of primary male sexual characteristics|
|sister chromatid segregation|
|spermatid development|
|meiotic nuclear division|
|male sex differentiation|
|spermatid differentiation|
|cell maturation|
|meiotic cell cycle process|
|fertilization|
|double-strand break repair|
|gonad development|
|development of primary sexual characteristics|
|nuclear chromosome segregation|
|DNA recombination|
|meiotic cell cycle|
|developmental maturation|
|germ cell development|
|sex differentiation|
|chromosome segregation|
|nuclear division|
|organelle fission|
|cellular process involved in reproduction in multicellular organism|
|chromatin binding|
|reproductive structure development|
|reproductive system development|
|DNA repair|
|spermatogenesis|
|male gamete generation|
|developmental process involved in reproduction|
|gamete generation|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|multi-organism reproductive process|
|cell cycle process|
|chromosome organization|
|cell cycle|
|reproductive process|
|reproduction|
|cell development|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.23|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.14|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-2.14|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-1.78|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.71|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.76|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7476
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='REC8 Expression in NALM6 Cells: 2.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>