RECQL4 [The Human Chemical-Genetic Interaction Map Project]

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======= RECQL4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RECQL4
  * **<color #00a2e8>Official Name</color>**: RecQ like helicase 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9401|9401]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94761|O94761]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RECQL4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RECQL4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603780|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. [provided by RefSeq, Jan 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  DNA-dependent ATPase. May modulate chromosome segregation. {ECO:0000269|PubMed:15317757}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DEAD|
|Helicase C|
|Drc1-Sld2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|telomeric D-loop binding|
|four-way junction helicase activity|
|annealing helicase activity|
|oxidized purine DNA binding|
|telomeric D-loop disassembly|
|bubble DNA binding|
|DNA strand renaturation|
|telomeric loop disassembly|
|DNA unwinding involved in DNA replication|
|3-5 DNA helicase activity|
|helicase activity|
|chromosome, telomeric region|
|double-strand break repair via homologous recombination|
|telomere maintenance|
|recombinational repair|
|telomere organization|
|DNA duplex unwinding|
|DNA geometric change|
|DNA-dependent DNA replication|
|chromosome|
|double-strand break repair|
|DNA replication|
|DNA recombination|
|DNA conformation change|
|anatomical structure homeostasis|
|DNA repair|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|chromosome organization|
|ATP binding|
|homeostatic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1802
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RECQL4 Expression in NALM6 Cells: 6.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>