REXO2 [The Human Chemical-Genetic Interaction Map Project]

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======= REXO2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: REXO2
  * **<color #00a2e8>Official Name</color>**: RNA exonuclease 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25996|25996]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3B8|Q9Y3B8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=REXO2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20REXO2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607149|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling. {ECO:0000269|PubMed:23741365}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RNase T|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|3-5 exonuclease activity|
|3-5-exoribonuclease activity|
|RNA phosphodiester bond hydrolysis, exonucleolytic|
|mitochondrial intermembrane space|
|RNA phosphodiester bond hydrolysis|
|nucleic acid binding|
|nucleic acid phosphodiester bond hydrolysis|
|mitochondrial matrix|
|focal adhesion|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|nucleobase-containing small molecule metabolic process|
|nucleolus|
|organophosphate metabolic process|
|mitochondrion|
|RNA metabolic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.71|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.77|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.78|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.89|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.89|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.97|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.99|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.01|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|2.17|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.19|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prepl|PREPL]]|0.474|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.45|
|[[:human genes:d:ddx28|DDX28]]|0.429|
|[[:human genes:c:ccdc90b|CCDC90B]]|0.421|
|[[:human genes:s:sfxn4|SFXN4]]|0.411|
|[[:human genes:t:tsfm|TSFM]]|0.407|
|[[:human genes:e:eral1|ERAL1]]|0.406|
|[[:human genes:y:ybey|YBEY]]|0.405|
|[[:human genes:p:pde12|PDE12]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 19/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|3/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 551
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='REXO2 Expression in NALM6 Cells: 4.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>