RFC3 [The Human Chemical-Genetic Interaction Map Project]

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======= RFC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RFC3
  * **<color #00a2e8>Official Name</color>**: replication factor C subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5983|5983]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P40938|P40938]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RFC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RFC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600405|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RFC-E C|
|AAA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA replication factor C complex|
|positive regulation of DNA-directed DNA polymerase activity|
|regulation of DNA-directed DNA polymerase activity|
|Ctf18 RFC-like complex|
|DNA clamp loader activity|
|single-stranded DNA helicase activity|
|DNA strand elongation involved in DNA replication|
|error-prone translesion synthesis|
|error-free translesion synthesis|
|DNA strand elongation|
|nucleotide-excision repair, DNA gap filling|
|telomere maintenance via semi-conservative replication|
|nucleotide-excision repair, DNA incision, 5-to lesion|
|DNA damage response, detection of DNA damage|
|nucleotide-excision repair, DNA incision|
|translesion synthesis|
|nuclear DNA replication|
|cell cycle DNA replication|
|DNA synthesis involved in DNA repair|
|postreplication repair|
|regulation of DNA-dependent DNA replication|
|positive regulation of DNA biosynthetic process|
|transcription-coupled nucleotide-excision repair|
|telomere maintenance|
|telomere organization|
|regulation of DNA replication|
|DNA biosynthetic process|
|nucleotide-excision repair|
|DNA duplex unwinding|
|regulation of DNA biosynthetic process|
|DNA geometric change|
|DNA-dependent DNA replication|
|response to organophosphorus|
|regulation of signal transduction by p53 class mediator|
|positive regulation of DNA metabolic process|
|DNA replication|
|ATPase activity|
|DNA conformation change|
|nucleic acid phosphodiester bond hydrolysis|
|anatomical structure homeostasis|
|regulation of DNA metabolic process|
|DNA repair|
|positive regulation of transferase activity|
|detection of stimulus|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular homeostasis|
|regulation of transferase activity|
|cell cycle process|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cell cycle|
|positive regulation of catalytic activity|
|DNA binding|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-2.62|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.25|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.21|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-1.84|
|[[:results:exp135|MS023 7μM R03 exp135]]|-1.79|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.75|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.74|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.7|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.81|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 734/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|15/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 221
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RFC3 Expression in NALM6 Cells: 6.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>