RFX7 [The Human Chemical-Genetic Interaction Map Project]

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======= RFX7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RFX7
  * **<color #00a2e8>Official Name</color>**: regulatory factor X7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64864|64864]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q2KHR2|Q2KHR2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RFX7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RFX7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612660|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RFX DNA binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|DNA-binding transcription factor activity|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.71|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.75|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.78|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.82|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|2.05|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.3|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.38|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|2.92|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|3.14|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|3.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rb1|RB1]]|0.428|
|[[:human genes:r:rfxap|RFXAP]]|0.419|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18359
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RFX7 Expression in NALM6 Cells: 6.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>