RGCC [The Human Chemical-Genetic Interaction Map Project]

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======= RGCC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RGCC
  * **<color #00a2e8>Official Name</color>**: regulator of cell cycle
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=28984|28984]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H4X1|Q9H4X1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RGCC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RGCC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610077|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. {ECO:0000269|PubMed:11687586, ECO:0000269|PubMed:17146433, ECO:0000269|PubMed:19158077, ECO:0000269|PubMed:22163048}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of exit from mitosis|
|negative regulation of fibroblast growth factor production|
|positive regulation of extracellular matrix constituent secretion|
|positive regulation of extracellular matrix assembly|
|fibroblast activation|
|regulation of extracellular matrix constituent secretion|
|negative regulation of cell-cell adhesion mediated by cadherin|
|regulation of fibroblast growth factor production|
|regulation of extracellular matrix assembly|
|mitotic cell cycle arrest|
|regulation of cell-cell adhesion mediated by cadherin|
|positive regulation of endothelial cell apoptotic process|
|regulation of exit from mitosis|
|positive regulation of extracellular matrix organization|
|R-SMAD binding|
|positive regulation of collagen biosynthetic process|
|positive regulation of collagen metabolic process|
|protein kinase activator activity|
|positive regulation of cyclin-dependent protein serine/threonine kinase activity|
|negative regulation of blood vessel endothelial cell migration|
|positive regulation of epithelial cell apoptotic process|
|regulation of collagen biosynthetic process|
|positive regulation of cyclin-dependent protein kinase activity|
|positive regulation of G1/S transition of mitotic cell cycle|
|negative regulation of endothelial cell proliferation|
|regulation of extracellular matrix organization|
|negative regulation of mitotic nuclear division|
|regulation of collagen metabolic process|
|positive regulation of cell cycle G1/S phase transition|
|positive regulation of epithelial to mesenchymal transition|
|negative regulation of nuclear division|
|negative regulation of endothelial cell migration|
|regulation of endothelial cell apoptotic process|
|positive regulation of stress fiber assembly|
|positive regulation of mitotic nuclear division|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|signal transduction involved in mitotic DNA integrity checkpoint|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|positive regulation of actin filament bundle assembly|
|mitotic G1/S transition checkpoint|
|mitotic G1 DNA damage checkpoint|
|G1 DNA damage checkpoint|
|positive regulation of nuclear division|
|negative regulation of epithelial cell migration|
|positive regulation of DNA biosynthetic process|
|negative regulation of cytokine secretion|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in cell cycle checkpoint|
|positive regulation of mitotic cell cycle phase transition|
|regulation of epithelial cell apoptotic process|
|regulation of stress fiber assembly|
|DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cell cycle arrest|
|regulation of epithelial to mesenchymal transition|
|regulation of actomyosin structure organization|
|regulation of blood vessel endothelial cell migration|
|regulation of actin filament bundle assembly|
|positive regulation of cell cycle phase transition|
|mitotic DNA damage checkpoint|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|negative regulation of G1/S transition of mitotic cell cycle|
|regulation of cyclin-dependent protein kinase activity|
|negative regulation of angiogenesis|
|signal transduction in response to DNA damage|
|mitotic DNA integrity checkpoint|
|negative regulation of blood vessel morphogenesis|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|regulation of DNA biosynthetic process|
|negative regulation of vasculature development|
|signal transduction by p53 class mediator|
|negative regulation of epithelial cell proliferation|
|regulation of endothelial cell proliferation|
|DNA damage checkpoint|
|negative regulation of protein secretion|
|negative regulation of peptide secretion|
|positive regulation of cytokine secretion|
|DNA integrity checkpoint|
|cell cycle arrest|
|regulation of G1/S transition of mitotic cell cycle|
|cytokine production|
|positive regulation of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|regulation of endothelial cell migration|
|regulation of cell cycle G1/S phase transition|
|regulation of mitotic nuclear division|
|negative regulation of cell-cell adhesion|
|complement activation|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|cellular response to hypoxia|
|regulation of nuclear division|
|positive regulation of DNA metabolic process|
|cell cycle checkpoint|
|positive regulation of supramolecular fiber organization|
|cellular response to decreased oxygen levels|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|negative regulation of mitotic cell cycle phase transition|
|cellular response to oxygen levels|
|regulation of epithelial cell migration|
|positive regulation of cytoskeleton organization|
|negative regulation of cell cycle phase transition|
|negative regulation of secretion|
|negative regulation of cell migration|
|regulation of actin filament organization|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of protein secretion|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|negative regulation of cytokine production|
|positive regulation of cell cycle process|
|regulation of angiogenesis|
|positive regulation of peptide secretion|
|negative regulation of mitotic cell cycle|
|negative regulation of cellular component movement|
|regulation of vasculature development|
|negative regulation of locomotion|
|negative regulation of cell cycle process|
|activation of protein kinase activity|
|regulation of epithelial cell proliferation|
|positive regulation of protein serine/threonine kinase activity|
|regulation of actin cytoskeleton organization|
|response to hypoxia|
|humoral immune response|
|regulation of supramolecular fiber organization|
|regulation of DNA metabolic process|
|response to decreased oxygen levels|
|negative regulation of organelle organization|
|positive regulation of cell cycle|
|response to oxygen levels|
|regulation of actin filament-based process|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|regulation of mitotic cell cycle phase transition|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|positive regulation of secretion|
|regulation of cell cycle phase transition|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|regulation of protein secretion|
|negative regulation of transport|
|centrosome|
|regulation of peptide secretion|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cellular component biogenesis|
|positive regulation of protein kinase activity|
|regulation of cytoskeleton organization|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|activation of immune response|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|mitotic cell cycle|
|regulation of cytokine production|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of cell migration|
|nucleolus|
|positive regulation of immune response|
|regulation of kinase activity|
|regulation of cell motility|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|cell cycle process|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|immune effector process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|regulation of organelle organization|
|cell cycle|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15151
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RGCC Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>