RGS4 [The Human Chemical-Genetic Interaction Map Project]

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======= RGS4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RGS4
  * **<color #00a2e8>Official Name</color>**: regulator of G protein signaling 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5999|5999]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49798|P49798]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RGS4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RGS4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602516|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RGS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of glycine import across plasma membrane|
|negative regulation of glycine import across plasma membrane|
|negative regulation of dopamine receptor signaling pathway|
|negative regulation of neurotransmitter uptake|
|dorsal root ganglion development|
|regulation of amino acid transmembrane transport|
|regulation of amino acid import across plasma membrane|
|negative regulation of amino acid transport|
|negative regulation of cell growth involved in cardiac muscle cell development|
|regulation of dopamine receptor signaling pathway|
|negative regulation of anion transmembrane transport|
|ganglion development|
|negative regulation of cardiac muscle cell differentiation|
|regulation of cell growth involved in cardiac muscle cell development|
|negative regulation of cellular response to drug|
|negative regulation of organic acid transport|
|regulation of neurotransmitter uptake|
|negative regulation of cardiocyte differentiation|
|negative regulation of heart growth|
|negative regulation of neurotransmitter transport|
|negative regulation of cardiac muscle tissue growth|
|negative regulation of potassium ion transmembrane transport|
|positive regulation of heart rate|
|G-protein alpha-subunit binding|
|negative regulation of amine transport|
|negative regulation of cardiac muscle hypertrophy|
|regulation of anion transmembrane transport|
|inactivation of MAPK activity|
|negative regulation of response to drug|
|positive regulation of excitatory postsynaptic potential|
|negative regulation of muscle hypertrophy|
|negative regulation of anion transport|
|negative regulation of organ growth|
|regulation of amino acid transport|
|response to amphetamine|
|negative regulation of cardiac muscle tissue development|
|negative regulation of potassium ion transport|
|response to morphine|
|response to isoquinoline alkaloid|
|regulation of cellular response to drug|
|regulation of cardiac muscle cell differentiation|
|negative regulation of striated muscle cell differentiation|
|positive regulation of heart contraction|
|modulation of excitatory postsynaptic potential|
|response to amine|
|negative regulation of striated muscle tissue development|
|negative regulation of muscle organ development|
|regulation of cardiocyte differentiation|
|response to bronchodilator|
|negative regulation of muscle tissue development|
|negative regulation of muscle cell differentiation|
|response to cocaine|
|regulation of cardiac muscle hypertrophy|
|regulation of cardiac muscle tissue growth|
|regulation of organic acid transport|
|regulation of muscle hypertrophy|
|positive regulation of nervous system process|
|regulation of heart growth|
|positive regulation of blood circulation|
|negative regulation of MAP kinase activity|
|response to anesthetic|
|regulation of cardiac muscle tissue development|
|regulation of potassium ion transmembrane transport|
|negative regulation of cation transmembrane transport|
|regulation of muscle adaptation|
|regulation of organ growth|
|regulation of amine transport|
|regulation of anion transport|
|negative regulation of ion transmembrane transport|
|regulation of potassium ion transport|
|regulation of heart rate|
|regulation of response to drug|
|regulation of striated muscle cell differentiation|
|negative regulation of developmental growth|
|response to alkaloid|
|negative regulation of transmembrane transport|
|response to ethanol|
|regulation of striated muscle tissue development|
|negative regulation of protein serine/threonine kinase activity|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|regulation of nervous system process|
|regulation of G protein-coupled receptor signaling pathway|
|regulation of neurotransmitter transport|
|negative regulation of ion transport|
|positive regulation of synaptic transmission|
|regulation of muscle cell differentiation|
|negative regulation of MAPK cascade|
|negative regulation of cell growth|
|response to ammonium ion|
|calmodulin binding|
|negative regulation of protein kinase activity|
|response to alcohol|
|regulation of muscle system process|
|negative regulation of growth|
|regulation of heart contraction|
|negative regulation of kinase activity|
|regulation of calcium ion transport|
|regulation of actin filament organization|
|negative regulation of transferase activity|
|GTPase activator activity|
|regulation of blood circulation|
|response to xenobiotic stimulus|
|response to antibiotic|
|regulation of developmental growth|
|GTPase activity|
|regulation of cation transmembrane transport|
|negative regulation of cell development|
|regulation of MAP kinase activity|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of neurotransmitter levels|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|negative regulation of protein phosphorylation|
|positive regulation of GTPase activity|
|regulation of cell growth|
|regulation of membrane potential|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|negative regulation of phosphorylation|
|regulation of ion transmembrane transport|
|regulation of GTPase activity|
|negative regulation of transport|
|response to toxic substance|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|regulation of cytoskeleton organization|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|regulation of system process|
|negative regulation of protein modification process|
|protein-containing complex|
|regulation of growth|
|regulation of ion transport|
|negative regulation of cell differentiation|
|brain development|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|head development|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|response to organic cyclic compound|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of transferase activity|
|central nervous system development|
|response to organonitrogen compound|
|response to drug|
|negative regulation of cellular protein metabolic process|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17045
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.22 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RGS4 Expression in NALM6 Cells: 0.22'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>