RHOC [The Human Chemical-Genetic Interaction Map Project]

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======= RHOC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RHOC
  * **<color #00a2e8>Official Name</color>**: ras homolog family member C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=389|389]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08134|P08134]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RHOC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RHOC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/165380|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:20974804}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Arf|
|Miro|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|skeletal muscle satellite cell migration|
|cell division site|
|positive regulation of protein homooligomerization|
|establishment or maintenance of actin cytoskeleton polarity|
|establishment or maintenance of cytoskeleton polarity|
|regulation of protein homooligomerization|
|positive regulation of protein oligomerization|
|wound healing, spreading of cells|
|epiboly involved in wound healing|
|epiboly|
|stereocilium|
|regulation of protein oligomerization|
|apical junction assembly|
|morphogenesis of an epithelial sheet|
|positive regulation of stress fiber assembly|
|cleavage furrow|
|positive regulation of actin filament bundle assembly|
|actin filament bundle assembly|
|actin filament bundle organization|
|mitotic cytokinesis|
|positive regulation of lipase activity|
|Rho protein signal transduction|
|regulation of stress fiber assembly|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|cytoskeleton-dependent cytokinesis|
|regulation of lipase activity|
|cytokinesis|
|cell-cell junction assembly|
|cell cortex|
|cell-cell junction organization|
|regulation of cell shape|
|cell junction assembly|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|establishment or maintenance of cell polarity|
|positive regulation of supramolecular fiber organization|
|cell junction organization|
|positive regulation of cytoskeleton organization|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|actin filament organization|
|Ras protein signal transduction|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|small GTPase mediated signal transduction|
|GTPase activity|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|regulation of supramolecular fiber organization|
|regulation of actin filament-based process|
|GTP binding|
|morphogenesis of an epithelium|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|protein kinase binding|
|wound healing|
|regulation of cell morphogenesis|
|cell division|
|actin cytoskeleton organization|
|positive regulation of cell migration|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of locomotion|
|tissue morphogenesis|
|actin filament-based process|
|response to wounding|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|mitotic cell cycle|
|intracellular membrane-bounded organelle|
|positive regulation of hydrolase activity|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cellular component biogenesis|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|cell cycle process|
|positive regulation of intracellular signal transduction|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|epithelium development|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|locomotion|
|G protein-coupled receptor signaling pathway|
|cell cycle|
|positive regulation of catalytic activity|
|movement of cell or subcellular component|
|positive regulation of signal transduction|
|intracellular signal transduction|
|tissue development|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.93|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.81|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|-1.77|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.73|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.72|
|[[:results:exp149|SB203580 25μM R03 exp149]]|1.7|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.85|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.91|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7833
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RHOC Expression in NALM6 Cells: 3.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>