RHOQ [The Human Chemical-Genetic Interaction Map Project]

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======= RHOQ =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RHOQ
  * **<color #00a2e8>Official Name</color>**: ras homolog family member Q
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23433|23433]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17081|P17081]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RHOQ&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RHOQ|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605857|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia. {ECO:0000269|PubMed:15546864}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Miro|
|Arf|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GBD domain binding|
|profilin binding|
|Golgi-associated vesicle membrane|
|negative regulation of protein localization to plasma membrane|
|negative regulation of protein localization to cell periphery|
|GTP metabolic process|
|negative regulation of protein localization to membrane|
|positive regulation of filopodium assembly|
|positive regulation of glucose import|
|guanosine-containing compound metabolic process|
|cortical actin cytoskeleton organization|
|positive regulation of glucose transmembrane transport|
|regulation of filopodium assembly|
|cortical cytoskeleton organization|
|regulation of glucose import|
|purine ribonucleoside triphosphate metabolic process|
|purine ribonucleoside metabolic process|
|purine nucleoside metabolic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|regulation of glucose transmembrane transport|
|ribonucleoside metabolic process|
|Rho protein signal transduction|
|actin filament|
|insulin receptor signaling pathway|
|nucleoside triphosphate metabolic process|
|regulation of protein localization to plasma membrane|
|cell projection|
|positive regulation of plasma membrane bounded cell projection assembly|
|nucleoside metabolic process|
|negative regulation of cellular protein localization|
|regulation of protein localization to cell periphery|
|glycosyl compound metabolic process|
|cell cortex|
|regulation of cell shape|
|cellular response to insulin stimulus|
|regulation of protein localization to membrane|
|establishment or maintenance of cell polarity|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|positive regulation of transmembrane transport|
|membrane raft|
|response to insulin|
|actin filament organization|
|Ras protein signal transduction|
|cellular response to peptide hormone stimulus|
|purine ribonucleotide metabolic process|
|small GTPase mediated signal transduction|
|ribonucleotide metabolic process|
|cellular response to peptide|
|GTPase activity|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|purine-containing compound metabolic process|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|GTP binding|
|response to peptide hormone|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|supramolecular fiber organization|
|cell projection assembly|
|protein kinase binding|
|response to peptide|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|positive regulation of cellular component biogenesis|
|regulation of cellular protein localization|
|nucleobase-containing small molecule metabolic process|
|regulation of cytoskeleton organization|
|endocytosis|
|regulation of transmembrane transport|
|actin filament-based process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|organophosphate metabolic process|
|response to hormone|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|response to organonitrogen compound|
|carbohydrate derivative metabolic process|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|cytoskeleton organization|
|cell projection organization|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|regulation of organelle organization|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|intracellular signal transduction|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|regulation of intracellular signal transduction|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 11/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6875
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RHOQ Expression in NALM6 Cells: 4.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>