RIF1 [The Human Chemical-Genetic Interaction Map Project]

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======= RIF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RIF1
  * **<color #00a2e8>Official Name</color>**: replication timing regulatory factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55183|55183]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5UIP0|Q5UIP0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RIF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RIF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608952|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that shares homology with the yeast teleomere binding protein, Rap1 interacting factor 1. This protein localizes to aberrant telomeres may be involved in DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rif1 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chromatin silencing at telomere|
|male pronucleus|
|female pronucleus|
|telomere maintenance in response to DNA damage|
|positive regulation of histone H3-K9 methylation|
|positive regulation of double-strand break repair via nonhomologous end joining|
|negative regulation of double-strand break repair via homologous recombination|
|regulation of histone H3-K9 methylation|
|regulation of double-strand break repair via nonhomologous end joining|
|spindle midzone|
|positive regulation of isotype switching|
|condensed chromosome|
|positive regulation of double-strand break repair|
|negative regulation of double-strand break repair|
|negative regulation of DNA repair|
|regulation of isotype switching|
|positive regulation of immunoglobulin mediated immune response|
|positive regulation of B cell mediated immunity|
|positive regulation of histone methylation|
|positive regulation of DNA recombination|
|positive regulation of immunoglobulin production|
|negative regulation of DNA recombination|
|regulation of double-strand break repair via homologous recombination|
|chromosome, telomeric region|
|regulation of immunoglobulin mediated immune response|
|regulation of B cell mediated immunity|
|double-strand break repair via nonhomologous end joining|
|site of double-strand break|
|chromatin silencing|
|chromatin organization involved in negative regulation of transcription|
|regulation of immunoglobulin production|
|non-recombinational repair|
|regulation of histone methylation|
|positive regulation of DNA repair|
|chromatin organization involved in regulation of transcription|
|regulation of double-strand break repair|
|negative regulation of response to DNA damage stimulus|
|negative regulation of gene expression, epigenetic|
|positive regulation of histone modification|
|response to leukemia inhibitory factor|
|positive regulation of production of molecular mediator of immune response|
|cellular response to leukemia inhibitory factor|
|telomere maintenance|
|positive regulation of response to DNA damage stimulus|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|telomere organization|
|regulation of DNA recombination|
|positive regulation of chromatin organization|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|negative regulation of DNA metabolic process|
|regulation of DNA repair|
|positive regulation of leukocyte mediated immunity|
|stem cell population maintenance|
|maintenance of cell number|
|regulation of production of molecular mediator of immune response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of histone modification|
|regulation of lymphocyte mediated immunity|
|gene silencing|
|regulation of adaptive immune response|
|positive regulation of B cell activation|
|positive regulation of chromosome organization|
|double-strand break repair|
|regulation of chromatin organization|
|positive regulation of DNA metabolic process|
|regulation of leukocyte mediated immunity|
|regulation of B cell activation|
|regulation of response to DNA damage stimulus|
|positive regulation of immune effector process|
|regulation of gene expression, epigenetic|
|nuclear chromatin|
|nuclear membrane|
|nuclear body|
|anatomical structure homeostasis|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|positive regulation of lymphocyte activation|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of immune effector process|
|DNA repair|
|regulation of lymphocyte activation|
|regulation of leukocyte activation|
|positive regulation of organelle organization|
|regulation of cell activation|
|chromatin organization|
|regulation of cellular response to stress|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|cellular response to cytokine stimulus|
|chromosome organization|
|response to cytokine|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|cell cycle|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-3.35|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.66|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-2.46|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.46|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.37|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-2.35|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-2.32|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.28|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.24|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.21|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.2|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.14|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-2.04|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.02|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.93|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.9|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.89|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.88|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.85|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-1.84|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.82|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.8|
|[[:results:exp115|A-366 10μM R03 exp115]]|-1.8|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.79|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.78|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.75|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-1.74|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.7|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.84|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.39|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6587
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RIF1 Expression in NALM6 Cells: 8.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>