RILPL2 [The Human Chemical-Genetic Interaction Map Project]

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======= RILPL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RILPL2
  * **<color #00a2e8>Official Name</color>**: Rab interacting lysosomal protein like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=196383|196383]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969X0|Q969X0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RILPL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RILPL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614093|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. Plays a role in cellular protein transport, including protein transport away from primary cilia. May function via activation of RAC1 and PAK1 (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RILP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein transport from ciliary membrane to plasma membrane|
|protein transport within lipid bilayer|
|small GTPase binding|
|dynein light intermediate chain binding|
|epithelial cell morphogenesis|
|establishment of protein localization to plasma membrane|
|localization within membrane|
|ciliary basal body|
|protein dimerization activity|
|protein localization to plasma membrane|
|epithelial cell development|
|cilium|
|protein localization to cell periphery|
|establishment of protein localization to membrane|
|cilium assembly|
|cilium organization|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|protein localization to membrane|
|centrosome|
|cell morphogenesis involved in differentiation|
|epithelial cell differentiation|
|cell morphogenesis|
|organelle assembly|
|cellular component morphogenesis|
|membrane organization|
|intracellular protein transport|
|identical protein binding|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cell development|
|tissue development|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.89|
|[[:results:exp519|RS-1 10μM R08 exp519]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.528|
|[[:human genes:p:psmd3|PSMD3]]|0.463|
|[[:human genes:p:prim1|PRIM1]]|0.459|
|[[:human genes:s:ssh2|SSH2]]|0.454|
|[[:human genes:c:ccdc116|CCDC116]]|0.452|
|[[:human genes:p:psmb4|PSMB4]]|0.451|
|[[:human genes:t:ticrr|TICRR]]|0.435|
|[[:human genes:f:fam160a1|FAM160A1]]|0.435|
|[[:human genes:c:cbwd3|CBWD3]]|0.433|
|[[:human genes:c:cbwd5|CBWD5]]|0.433|
|[[:human genes:c:cwc22|CWC22]]|0.432|
|[[:human genes:n:nupl1|NUPL1]]|0.432|
|[[:human genes:h:hap1|HAP1]]|0.428|
|[[:human genes:p:psma6|PSMA6]]|0.427|
|[[:human genes:v:vasn|VASN]]|0.425|
|[[:human genes:t:tfip11|TFIP11]]|0.424|
|[[:human genes:r:rps12|RPS12]]|0.422|
|[[:human genes:r:rpl35|RPL35]]|0.421|
|[[:human genes:n:nbpf10|NBPF10]]|0.417|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.417|
|[[:human genes:d:ddtl|DDTL]]|0.415|
|[[:human genes:t:twistnb|TWISTNB]]|0.414|
|[[:human genes:c:copg1|COPG1]]|0.414|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.413|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.412|
|[[:human genes:k:krt78|KRT78]]|0.41|
|[[:human genes:c:cdc45|CDC45]]|0.409|
|[[:human genes:p:pola2|POLA2]]|0.408|
|[[:human genes:s:supt5h|SUPT5H]]|0.408|
|[[:human genes:p:pola1|POLA1]]|0.408|
|[[:human genes:c:c14orf93|C14orf93]]|0.407|
|[[:human genes:r:riok2|RIOK2]]|0.407|
|[[:human genes:c:cbwd6|CBWD6]]|0.406|
|[[:human genes:m:mdm2|MDM2]]|0.405|
|[[:human genes:t:tceb3c|TCEB3C]]|0.404|
|[[:human genes:s:slc38a7|SLC38A7]]|0.404|
|[[:human genes:d:ddt|DDT]]|0.403|
|[[:human genes:f:fam25b|FAM25B]]|0.403|
|[[:human genes:k:kctd17|KCTD17]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2236
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RILPL2 Expression in NALM6 Cells: 5.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>