RIMS2 [The Human Chemical-Genetic Interaction Map Project]

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======= RIMS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RIMS2
  * **<color #00a2e8>Official Name</color>**: regulating synaptic membrane exocytosis 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9699|9699]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UQ26|Q9UQ26]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RIMS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RIMS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606630|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDZ|
|C2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoskeleton of presynaptic active zone|
|spontaneous neurotransmitter secretion|
|positive regulation of inhibitory postsynaptic potential|
|modulation of inhibitory postsynaptic potential|
|spontaneous synaptic transmission|
|presynaptic active zone cytoplasmic component|
|calcium ion-regulated exocytosis of neurotransmitter|
|positive regulation of dendrite extension|
|regulation of dendrite extension|
|positive regulation of excitatory postsynaptic potential|
|presynaptic active zone|
|insulin secretion|
|modulation of excitatory postsynaptic potential|
|calcium-ion regulated exocytosis|
|peptide hormone secretion|
|positive regulation of nervous system process|
|synaptic vesicle exocytosis|
|hormone secretion|
|presynaptic membrane|
|regulation of synaptic vesicle exocytosis|
|hormone transport|
|signal release from synapse|
|neurotransmitter secretion|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|synaptic vesicle cycle|
|ion channel binding|
|vesicle-mediated transport in synapse|
|regulation of nervous system process|
|regulation of neurotransmitter transport|
|cAMP-mediated signaling|
|Rab GTPase binding|
|positive regulation of synaptic transmission|
|protein secretion|
|establishment of protein localization to extracellular region|
|positive regulation of cell growth|
|regulation of regulated secretory pathway|
|protein localization to extracellular region|
|signal release|
|positive regulation of developmental growth|
|cyclic-nucleotide-mediated signaling|
|peptide secretion|
|neurotransmitter transport|
|regulation of synaptic plasticity|
|regulation of exocytosis|
|positive regulation of growth|
|synapse|
|positive regulation of neuron projection development|
|regulation of developmental growth|
|second-messenger-mediated signaling|
|regulation of neurotransmitter levels|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|regulation of cell growth|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|regulation of membrane potential|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|regulation of hormone levels|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell junction|
|regulation of vesicle-mediated transport|
|regulation of system process|
|regulation of neuron differentiation|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|regulated exocytosis|
|regulation of cell projection organization|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|regulation of neurogenesis|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|intracellular protein transport|
|secretion by cell|
|export from cell|
|regulation of anatomical structure morphogenesis|
|cell-cell signaling|
|secretion|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.97|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|1.9|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.03|
|[[:results:exp218|A-395 10μM R05 exp218]]|2.07|
|[[:results:exp17|DABN 20μM R00 exp17]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14461
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RIMS2 Expression in NALM6 Cells: 3.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>