RINT1 [The Human Chemical-Genetic Interaction Map Project]

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======= RINT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RINT1
  * **<color #00a2e8>Official Name</color>**: RAD50 interactor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=60561|60561]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6NUQ1|Q6NUQ1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RINT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RINT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610089|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein first identified for its ability to interact with the RAD50 double strand break repair protein, with the resulting interaction implicated in the regulation of cell cycle progression and telomere length. The encoded protein may also play a role in trafficking of cellular cargo from the endosome to the trans-Golgi network. Mutations in this gene may be associated with breast cancer in human patients. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control (PubMed:11096100). Essential for telomere length control (PubMed:16600870). {ECO:0000269|PubMed:11096100, ECO:0000269|PubMed:16600870, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RINT1 TIP1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of signal transduction involved in mitotic G2 DNA damage checkpoint|
|regulation of mitotic DNA damage checkpoint|
|Dsl1/NZR complex|
|regulation of DNA damage checkpoint|
|regulation of ER to Golgi vesicle-mediated transport|
|regulation of cell cycle checkpoint|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|regulation of response to DNA damage stimulus|
|regulation of intracellular transport|
|Golgi vesicle transport|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|regulation of vesicle-mediated transport|
|regulation of mitotic cell cycle|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|endoplasmic reticulum|
|regulation of cell cycle|
|cell cycle|
|regulation of response to stress|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp539|42°C R08 exp539]]|-2.31|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.08|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.85|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.84|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vps54|VPS54]]|0.426|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 30/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|1/20|
|lung|5/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|2/24|
|peripheral nervous system|2/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1843
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RINT1 Expression in NALM6 Cells: 5.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>