RMND1 [The Human Chemical-Genetic Interaction Map Project]

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======= RMND1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RMND1
  * **<color #00a2e8>Official Name</color>**: required for meiotic nuclear division 1 homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55005|55005]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NWS8|Q9NWS8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RMND1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RMND1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614917|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the evolutionary conserved sif2 family of proteins that share the DUF155 domain in common. This protein is thought to be localized in the mitochondria and involved in mitochondrial translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-11. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome (PubMed:23022098, PubMed:25604853). {ECO:0000269|PubMed:23022098, ECO:0000269|PubMed:25604853}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF155|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mitochondrial translation|
|regulation of mitochondrial translation|
|regulation of mitochondrial gene expression|
|positive regulation of translation|
|positive regulation of cellular amide metabolic process|
|regulation of translation|
|translation|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.73|
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.76|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.78|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.86|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.93|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.94|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.03|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.04|
|[[:results:exp483|FTY720 3μM R08 exp483]]|2.06|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.42|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fastkd2|FASTKD2]]|0.581|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.565|
|[[:human genes:p:pet117|PET117]]|0.543|
|[[:human genes:g:grsf1|GRSF1]]|0.535|
|[[:human genes:p:prepl|PREPL]]|0.527|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.501|
|[[:human genes:m:mtif2|MTIF2]]|0.499|
|[[:human genes:c:cars2|CARS2]]|0.493|
|[[:human genes:n:ndufb10|NDUFB10]]|0.489|
|[[:human genes:n:nubpl|NUBPL]]|0.48|
|[[:human genes:n:nsun3|NSUN3]]|0.476|
|[[:human genes:m:mto1|MTO1]]|0.475|
|[[:human genes:n:ndufc1|NDUFC1]]|0.472|
|[[:human genes:n:nsun4|NSUN4]]|0.472|
|[[:human genes:e:eral1|ERAL1]]|0.468|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.465|
|[[:human genes:n:ndufs2|NDUFS2]]|0.465|
|[[:human genes:t:trit1|TRIT1]]|0.464|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.464|
|[[:human genes:a:acad9|ACAD9]]|0.459|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.452|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.451|
|[[:human genes:t:tomm7|TOMM7]]|0.45|
|[[:human genes:c:cox18|COX18]]|0.449|
|[[:human genes:m:mrps18b|MRPS18B]]|0.448|
|[[:human genes:p:pde12|PDE12]]|0.448|
|[[:human genes:c:cox6a1|COX6A1]]|0.447|
|[[:human genes:n:ndufa2|NDUFA2]]|0.446|
|[[:human genes:n:ndufs5|NDUFS5]]|0.443|
|[[:human genes:t:tfb1m|TFB1M]]|0.442|
|[[:human genes:n:ndufa8|NDUFA8]]|0.439|
|[[:human genes:n:ndufs8|NDUFS8]]|0.439|
|[[:human genes:m:malsu1|MALSU1]]|0.436|
|[[:human genes:m:mrps27|MRPS27]]|0.433|
|[[:human genes:m:mrpl1|MRPL1]]|0.432|
|[[:human genes:y:ybey|YBEY]]|0.427|
|[[:human genes:m:mcat|MCAT]]|0.426|
|[[:human genes:l:lars2|LARS2]]|0.426|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.423|
|[[:human genes:n:noa1|NOA1]]|0.423|
|[[:human genes:n:ndufa11|NDUFA11]]|0.423|
|[[:human genes:m:mrpl22|MRPL22]]|0.421|
|[[:human genes:n:ndufv2|NDUFV2]]|0.418|
|[[:human genes:n:ndufa6|NDUFA6]]|0.415|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.413|
|[[:human genes:c:ccdc90b|CCDC90B]]|0.409|
|[[:human genes:s:sfxn4|SFXN4]]|0.408|
|[[:human genes:c:clpp|CLPP]]|0.406|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.406|
|[[:human genes:n:ndufb11|NDUFB11]]|0.405|
|[[:human genes:p:ptcd3|PTCD3]]|0.403|
|[[:human genes:c:coq2|COQ2]]|0.401|
|[[:human genes:n:ndufa1|NDUFA1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1466
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RMND1 Expression in NALM6 Cells: 4.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>