RMND5A [The Human Chemical-Genetic Interaction Map Project]

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======= RMND5A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RMND5A
  * **<color #00a2e8>Official Name</color>**: required for meiotic nuclear division 5 homolog A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64795|64795]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H871|Q9H871]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RMND5A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RMND5A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618964|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GID complex|
|ubiquitin ligase complex|
|ubiquitin-protein transferase activity|
|protein polyubiquitination|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|protein modification by small protein conjugation|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.29|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.27|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.24|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-2.12|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-2.1|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-2.07|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.04|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-2|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.99|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.86|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-1.85|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.84|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.19|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.21|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.43|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.52|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.87|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|3.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:maea|MAEA]]|0.662|
|[[:human genes:g:gid8|GID8]]|0.654|
|[[:human genes:u:ube2h|UBE2H]]|0.543|
|[[:human genes:w:wdr26|WDR26]]|0.506|
|[[:human genes:y:ypel5|YPEL5]]|0.424|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 11/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|4/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15587
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RMND5A Expression in NALM6 Cells: 7.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>