RNF34 [The Human Chemical-Genetic Interaction Map Project]

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======= RNF34 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RNF34
  * **<color #00a2e8>Official Name</color>**: ring finger protein 34
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80196|80196]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969K3|Q969K3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNF34&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNF34|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608299|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219). {ECO:0000269|PubMed:12118383, ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:15897238, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:22064484, ECO:0000269|PubMed:25012219, ECO:0000269|Ref.13, ECO:0000303|PubMed:18382127}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of oxygen metabolic process|
|negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis|
|regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis|
|cellular response to cold|
|phosphatidylinositol phosphate binding|
|negative regulation of execution phase of apoptosis|
|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|
|negative regulation of signal transduction by p53 class mediator|
|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|regulation of execution phase of apoptosis|
|response to cold|
|protein K48-linked ubiquitination|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|p53 binding|
|endomembrane system|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of cysteine-type endopeptidase activity|
|negative regulation of extrinsic apoptotic signaling pathway|
|regulation of extrinsic apoptotic signaling pathway|
|intracellular receptor signaling pathway|
|response to temperature stimulus|
|regulation of signal transduction by p53 class mediator|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|ubiquitin protein ligase activity|
|negative regulation of apoptotic signaling pathway|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|nuclear body|
|ubiquitin protein ligase binding|
|protein polyubiquitination|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|negative regulation of proteolysis|
|regulation of apoptotic signaling pathway|
|nuclear speck|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|negative regulation of intracellular signal transduction|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|regulation of proteolysis|
|protein modification by small protein conjugation|
|negative regulation of catalytic activity|
|negative regulation of apoptotic process|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|apoptotic process|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|cell death|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|negative regulation of signal transduction|
|proteolysis|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of apoptotic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|regulation of cell death|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.85|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.83|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|1.85|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.85|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.87|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16938
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNF34 Expression in NALM6 Cells: 5.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>