RNGTT [The Human Chemical-Genetic Interaction Map Project]

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======= RNGTT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RNGTT
  * **<color #00a2e8>Official Name</color>**: RNA guanylyltransferase and 5'-phosphatase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8732|8732]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60942|O60942]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNGTT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNGTT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603512|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus. {ECO:0000269|PubMed:21636784, ECO:0000269|PubMed:9473487, ECO:0000269|PubMed:9512541}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|mRNA cap C|
|DSPc|
|mRNA cap enzyme|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|triphosphatase activity|
|RNA guanylyltransferase activity|
|mRNA guanylyltransferase activity|
|polynucleotide 5-phosphatase activity|
|polynucleotide 5 dephosphorylation|
|7-methylguanosine mRNA capping|
|RNA capping|
|7-methylguanosine RNA capping|
|protein tyrosine/serine/threonine phosphatase activity|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|protein dephosphorylation|
|dephosphorylation|
|GTP binding|
|mRNA processing|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.41|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.19|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-2.18|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.89|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.87|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-1.74|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.74|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.71|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.7|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.71|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 738/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 203
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNGTT Expression in NALM6 Cells: 5.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>