ROR2 [The Human Chemical-Genetic Interaction Map Project]

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======= ROR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ROR2
  * **<color #00a2e8>Official Name</color>**: receptor tyrosine kinase like orphan receptor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4920|4920]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01974|Q01974]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ROR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ROR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602337|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors.  The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development.  Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443). {ECO:0000250|UniProtKB:Q9Z138, ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:25029443}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fz|
|I-set|
|Pkinase|
|Pkinase Tyr|
|Kringle|
|ig|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|embryonic genitalia morphogenesis|
|regulation of protein kinase C activity|
|positive regulation of protein kinase C activity|
|coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway|
|positive regulation of macrophage differentiation|
|genitalia morphogenesis|
|mitogen-activated protein kinase kinase kinase binding|
|macrophage migration|
|cartilage condensation|
|regulation of macrophage differentiation|
|cell aggregation|
|male genitalia development|
|positive regulation of synaptic transmission, glutamatergic|
|clathrin-coated endocytic vesicle membrane|
|astrocyte development|
|Wnt-protein binding|
|Wnt signaling pathway, calcium modulating pathway|
|frizzled binding|
|genitalia development|
|bone mineralization|
|astrocyte differentiation|
|transmembrane receptor protein tyrosine kinase activity|
|positive regulation of myeloid leukocyte differentiation|
|SMAD protein signal transduction|
|embryonic digit morphogenesis|
|somitogenesis|
|regulation of synaptic transmission, glutamatergic|
|positive regulation of JUN kinase activity|
|smoothened signaling pathway|
|JNK cascade|
|somite development|
|regulation of JUN kinase activity|
|BMP signaling pathway|
|positive regulation of myeloid cell differentiation|
|biomineralization|
|biomineral tissue development|
|segmentation|
|Wnt signaling pathway, planar cell polarity pathway|
|inner ear morphogenesis|
|response to BMP|
|cellular response to BMP stimulus|
|stress-activated MAPK cascade|
|glial cell development|
|regulation of establishment of planar polarity|
|regulation of myeloid leukocyte differentiation|
|ear morphogenesis|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|myeloid leukocyte migration|
|non-canonical Wnt signaling pathway|
|positive regulation of JNK cascade|
|stress-activated protein kinase signaling cascade|
|positive regulation of canonical Wnt signaling pathway|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|positive regulation of leukocyte differentiation|
|appendage morphogenesis|
|limb morphogenesis|
|positive regulation of synaptic transmission|
|male sex differentiation|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|glial cell differentiation|
|cartilage development|
|negative regulation of canonical Wnt signaling pathway|
|positive regulation of Wnt signaling pathway|
|regulation of morphogenesis of an epithelium|
|appendage development|
|limb development|
|regulation of JNK cascade|
|positive regulation of hemopoiesis|
|inner ear development|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|receptor complex|
|negative regulation of Wnt signaling pathway|
|gliogenesis|
|anterior/posterior pattern specification|
|ear development|
|connective tissue development|
|regulation of myeloid cell differentiation|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|skeletal system morphogenesis|
|cell fate commitment|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|ossification|
|positive regulation of MAP kinase activity|
|sex differentiation|
|regulation of leukocyte differentiation|
|regulation of canonical Wnt signaling pathway|
|embryonic organ morphogenesis|
|axon|
|microtubule|
|regionalization|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|MAPK cascade|
|neuronal cell body|
|leukocyte migration|
|signal transduction by protein phosphorylation|
|dendrite|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|reproductive system development|
|embryonic organ development|
|pattern specification process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of hemopoiesis|
|skeletal system development|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|sensory organ development|
|positive regulation of locomotion|
|embryonic morphogenesis|
|positive regulation of kinase activity|
|cell surface|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|positive regulation of transferase activity|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|regulation of cell migration|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3753
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ROR2 Expression in NALM6 Cells: -1.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>