RPE [The Human Chemical-Genetic Interaction Map Project]

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======= RPE =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPE
  * **<color #00a2e8>Official Name</color>**: ribulose-5-phosphate-3-epimerase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6120|6120]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96AT9|Q96AT9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPE&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPE|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180480|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribul P 3 epim|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribulose-phosphate 3-epimerase activity|
|pentose catabolic process|
|pentose-phosphate shunt, non-oxidative branch|
|pentose-phosphate shunt|
|pentose metabolic process|
|NADPH regeneration|
|glucose 6-phosphate metabolic process|
|NADP metabolic process|
|monosaccharide catabolic process|
|carbohydrate catabolic process|
|cellular carbohydrate metabolic process|
|monosaccharide metabolic process|
|generation of precursor metabolites and energy|
|small molecule catabolic process|
|carbohydrate metabolic process|
|protein homodimerization activity|
|organophosphate metabolic process|
|oxidation-reduction process|
|carbohydrate derivative metabolic process|
|identical protein binding|
|small molecule metabolic process|
|organic substance catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-2.57|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2.48|
|[[:results:exp218|A-395 10μM R05 exp218]]|-2.45|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-2.42|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-2.36|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2.27|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-2.23|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-2.23|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-2.08|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-2.08|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-2.07|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-2.06|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-2.05|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-2.02|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-1.97|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.97|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.97|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.96|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-1.96|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.94|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.91|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.91|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.89|
|[[:results:exp519|RS-1 10μM R08 exp519]]|-1.89|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-1.88|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-1.85|
|[[:results:exp392|PT-1 25μM R07 exp392]]|-1.85|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.8|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.76|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.74|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.7|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.71|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.72|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.79|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.8|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.84|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.85|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.85|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.87|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.91|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.92|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.01|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.02|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.02|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.13|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.21|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.22|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.25|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.32|
|[[:results:exp539|42°C R08 exp539]]|2.33|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.33|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.45|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.51|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.53|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.55|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|2.57|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|2.61|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.63|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.72|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|3.16|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tkt|TKT]]|0.77|
|[[:human genes:t:triap1|TRIAP1]]|0.673|
|[[:human genes:p:pmm2|PMM2]]|0.645|
|[[:human genes:s:slc25a26|SLC25A26]]|0.614|
|[[:human genes:d:dpagt1|DPAGT1]]|0.594|
|[[:human genes:s:srp14|SRP14]]|0.593|
|[[:human genes:c:crls1|CRLS1]]|0.584|
|[[:human genes:a:alg1|ALG1]]|0.582|
|[[:human genes:r:romo1|ROMO1]]|0.581|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.571|
|[[:human genes:e:eno1|ENO1]]|0.57|
|[[:human genes:t:thg1l|THG1L]]|0.569|
|[[:human genes:t:tamm41|TAMM41]]|0.566|
|[[:human genes:u:uap1|UAP1]]|0.557|
|[[:human genes:h:hars|HARS]]|0.554|
|[[:human genes:a:adsl|ADSL]]|0.54|
|[[:human genes:a:atxn10|ATXN10]]|0.538|
|[[:human genes:t:taz|TAZ]]|0.538|
|[[:human genes:r:rptor|RPTOR]]|0.537|
|[[:human genes:g:gmppb|GMPPB]]|0.537|
|[[:human genes:r:rtcb|RTCB]]|0.536|
|[[:human genes:r:rpia|RPIA]]|0.533|
|[[:human genes:u:utp23|UTP23]]|0.532|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.528|
|[[:human genes:a:alg5|ALG5]]|0.527|
|[[:human genes:r:rpp21|RPP21]]|0.523|
|[[:human genes:e:exoc4|EXOC4]]|0.523|
|[[:human genes:d:dohh|DOHH]]|0.514|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.513|
|[[:human genes:r:rad1|RAD1]]|0.513|
|[[:human genes:t:tpi1|TPI1]]|0.502|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.501|
|[[:human genes:h:haus8|HAUS8]]|0.5|
|[[:human genes:b:bcs1l|BCS1L]]|0.499|
|[[:human genes:a:atic|ATIC]]|0.498|
|[[:human genes:g:gfpt1|GFPT1]]|0.497|
|[[:human genes:d:dhrsx|DHRSX]]|0.497|
|[[:human genes:u:urm1|URM1]]|0.496|
|[[:human genes:t:tmem41b|TMEM41B]]|0.493|
|[[:human genes:p:pgp|PGP]]|0.493|
|[[:human genes:d:dhps|DHPS]]|0.493|
|[[:human genes:v:vezt|VEZT]]|0.491|
|[[:human genes:u:uhrf1|UHRF1]]|0.49|
|[[:human genes:v:vrk1|VRK1]]|0.487|
|[[:human genes:r:rbmx2|RBMX2]]|0.487|
|[[:human genes:d:dpf2|DPF2]]|0.484|
|[[:human genes:t:trmt5|TRMT5]]|0.483|
|[[:human genes:a:alg13|ALG13]]|0.482|
|[[:human genes:n:nsmce1|NSMCE1]]|0.48|
|[[:human genes:e:elp3|ELP3]]|0.48|
|[[:human genes:e:eny2|ENY2]]|0.478|
|[[:human genes:p:pgm3|PGM3]]|0.475|
|[[:human genes:c:chchd4|CHCHD4]]|0.474|
|[[:human genes:a:alg6|ALG6]]|0.471|
|[[:human genes:z:zrsr2|ZRSR2]]|0.471|
|[[:human genes:t:timm13|TIMM13]]|0.471|
|[[:human genes:d:ddx20|DDX20]]|0.471|
|[[:human genes:p:pgls|PGLS]]|0.471|
|[[:human genes:u:ube2j1|UBE2J1]]|0.47|
|[[:human genes:p:pkm|PKM]]|0.469|
|[[:human genes:t:txnl4b|TXNL4B]]|0.467|
|[[:human genes:t:timm8b|TIMM8B]]|0.464|
|[[:human genes:p:ppcs|PPCS]]|0.464|
|[[:human genes:h:hspd1|HSPD1]]|0.463|
|[[:human genes:t:tbca|TBCA]]|0.463|
|[[:human genes:p:pgk1|PGK1]]|0.462|
|[[:human genes:g:gemin8|GEMIN8]]|0.46|
|[[:human genes:p:ppp4c|PPP4C]]|0.46|
|[[:human genes:t:tti2|TTI2]]|0.459|
|[[:human genes:t:tgs1|TGS1]]|0.459|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.458|
|[[:human genes:s:sec62|SEC62]]|0.458|
|[[:human genes:e:eprs|EPRS]]|0.458|
|[[:human genes:h:hccs|HCCS]]|0.457|
|[[:human genes:g:gnb1l|GNB1L]]|0.457|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.456|
|[[:human genes:l:lsm10|LSM10]]|0.456|
|[[:human genes:o:opa1|OPA1]]|0.455|
|[[:human genes:c:cct7|CCT7]]|0.454|
|[[:human genes:a:alg2|ALG2]]|0.454|
|[[:human genes:d:dhx30|DHX30]]|0.454|
|[[:human genes:g:gemin6|GEMIN6]]|0.454|
|[[:human genes:e:elac2|ELAC2]]|0.453|
|[[:human genes:r:rabggtb|RABGGTB]]|0.452|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.452|
|[[:human genes:a:alg14|ALG14]]|0.451|
|[[:human genes:p:pelo|PELO]]|0.45|
|[[:human genes:e:eif3f|EIF3F]]|0.45|
|[[:human genes:d:dnlz|DNLZ]]|0.449|
|[[:human genes:c:cbx3|CBX3]]|0.449|
|[[:human genes:t:tsen54|TSEN54]]|0.449|
|[[:human genes:t:tufm|TUFM]]|0.448|
|[[:human genes:a:aars|AARS]]|0.447|
|[[:human genes:m:mrps14|MRPS14]]|0.445|
|[[:human genes:g:gemin5|GEMIN5]]|0.444|
|[[:human genes:r:rnmt|RNMT]]|0.443|
|[[:human genes:y:yars2|YARS2]]|0.442|
|[[:human genes:m:mrps11|MRPS11]]|0.44|
|[[:human genes:c:casp9|CASP9]]|0.439|
|[[:human genes:s:sco2|SCO2]]|0.438|
|[[:human genes:c:c11orf57|C11orf57]]|0.438|
|[[:human genes:p:plaa|PLAA]]|0.438|
|[[:human genes:a:atp5j|ATP5J]]|0.436|
|[[:human genes:p:pam16|PAM16]]|0.434|
|[[:human genes:n:nae1|NAE1]]|0.432|
|[[:human genes:m:mapk14|MAPK14]]|0.432|
|[[:human genes:s:ssb|SSB]]|0.432|
|[[:human genes:t:ten1|TEN1]]|0.432|
|[[:human genes:u:uxt|UXT]]|0.431|
|[[:human genes:y:yars|YARS]]|0.431|
|[[:human genes:d:ddx55|DDX55]]|0.431|
|[[:human genes:o:otud5|OTUD5]]|0.43|
|[[:human genes:c:ctc1|CTC1]]|0.429|
|[[:human genes:g:gemin7|GEMIN7]]|0.429|
|[[:human genes:s:sars2|SARS2]]|0.428|
|[[:human genes:e:eif4e|EIF4E]]|0.428|
|[[:human genes:m:mrps34|MRPS34]]|0.427|
|[[:human genes:p:pdss1|PDSS1]]|0.427|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.426|
|[[:human genes:c:cops8|COPS8]]|0.425|
|[[:human genes:w:wdr24|WDR24]]|0.424|
|[[:human genes:b:bap1|BAP1]]|0.424|
|[[:human genes:t:trmt10a|TRMT10A]]|0.423|
|[[:human genes:a:atp5a1|ATP5A1]]|0.422|
|[[:human genes:k:kdm8|KDM8]]|0.422|
|[[:human genes:d:dnajb6|DNAJB6]]|0.421|
|[[:human genes:c:csnk2b|CSNK2B]]|0.421|
|[[:human genes:t:tprkb|TPRKB]]|0.421|
|[[:human genes:c:coq3|COQ3]]|0.42|
|[[:human genes:p:pggt1b|PGGT1B]]|0.419|
|[[:human genes:r:rbfa|RBFA]]|0.418|
|[[:human genes:t:tmem208|TMEM208]]|0.418|
|[[:human genes:k:kctd5|KCTD5]]|0.418|
|[[:human genes:o:osgep|OSGEP]]|0.417|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.417|
|[[:human genes:f:fh|FH]]|0.417|
|[[:human genes:m:mrps18a|MRPS18A]]|0.415|
|[[:human genes:s:sec61g|SEC61G]]|0.413|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.413|
|[[:human genes:m:mrpl21|MRPL21]]|0.413|
|[[:human genes:u:ube2g2|UBE2G2]]|0.413|
|[[:human genes:r:rpusd4|RPUSD4]]|0.412|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.412|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.411|
|[[:human genes:p:prkrip1|PRKRIP1]]|0.411|
|[[:human genes:h:hist1h4i|HIST1H4I]]|0.411|
|[[:human genes:c:cycs|CYCS]]|0.411|
|[[:human genes:b:bak1|BAK1]]|0.411|
|[[:human genes:c:c17orf89|C17orf89]]|0.41|
|[[:human genes:n:naa20|NAA20]]|0.41|
|[[:human genes:b:brwd1|BRWD1]]|0.407|
|[[:human genes:g:gfm2|GFM2]]|0.407|
|[[:human genes:e:exoc3|EXOC3]]|0.407|
|[[:human genes:d:dad1|DAD1]]|0.405|
|[[:human genes:o:oraov1|ORAOV1]]|0.405|
|[[:human genes:s:serf2|SERF2]]|0.405|
|[[:human genes:z:znhit1|ZNHIT1]]|0.404|
|[[:human genes:m:mrps6|MRPS6]]|0.404|
|[[:human genes:n:naf1|NAF1]]|0.404|
|[[:human genes:s:spr|SPR]]|0.403|
|[[:human genes:c:cep57|CEP57]]|0.403|
|[[:human genes:c:cmtr2|CMTR2]]|0.403|
|[[:human genes:t:tbcd|TBCD]]|0.4|
|[[:human genes:u:ube2k|UBE2K]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 377/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|12/28|
|blood|11/28|
|bone|10/26|
|breast|20/33|
|central nervous system|24/56|
|cervix|2/4|
|colorectal|6/17|
|esophagus|10/13|
|fibroblast|0/1|
|gastric|8/16|
|kidney|17/21|
|liver|8/20|
|lung|39/75|
|lymphocyte|7/16|
|ovary|9/26|
|pancreas|13/24|
|peripheral nervous system|10/16|
|plasma cell|7/15|
|prostate|0/1|
|skin|18/24|
|soft tissue|4/9|
|thyroid|1/2|
|upper aerodigestive|8/22|
|urinary tract|13/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2503
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPE Expression in NALM6 Cells: 5.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>