RPF1 [The Human Chemical-Genetic Interaction Map Project]

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======= RPF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPF1
  * **<color #00a2e8>Official Name</color>**: ribosome production factor 1 homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80135|80135]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H9Y2|Q9H9Y2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be required for ribosome biogenesis. {ECO:0000269|PubMed:11864606}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Brix|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|preribosome, large subunit precursor|
|rRNA binding|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp534|Trientine 500μM R08 exp534]]|-2.05|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.94|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.85|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.84|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.83|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.82|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.81|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.78|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.7|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.75|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.76|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|1.89|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|1.89|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cgb2|CGB2]]|0.449|
|[[:human genes:s:sde2|SDE2]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 139/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|3/28|
|bone|7/26|
|breast|1/33|
|central nervous system|11/56|
|cervix|1/4|
|colorectal|7/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|5/21|
|liver|2/20|
|lung|14/75|
|lymphocyte|2/16|
|ovary|2/26|
|pancreas|8/24|
|peripheral nervous system|1/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|11/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1945
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPF1 Expression in NALM6 Cells: 5.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>