RPL18 [The Human Chemical-Genetic Interaction Map Project]

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======= RPL18 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPL18
  * **<color #00a2e8>Official Name</color>**: ribosomal protein L18
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6141|6141]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q07020|Q07020]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPL18&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPL18|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604179|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the large ribosomal subunit. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000305|PubMed:12962325}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L18e|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|polysomal ribosome|
|rough endoplasmic reticulum|
|cytosolic large ribosomal subunit|
|cytoplasmic translation|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|establishment of protein localization to membrane|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|nucleolus|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|endoplasmic reticulum|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.74|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.67|
|[[:results:exp136|MS094 2μM R03 exp136]]|-2.11|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-2.08|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-2|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.96|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.96|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-1.9|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.87|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.82|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.8|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|-1.77|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.7|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.84|
|[[:results:exp132|Metformin 40μM R03 exp132]]|1.89|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.02|
|[[:results:exp114|A-196 10μM R03 exp114]]|2.09|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.1|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psma7|PSMA7]]|0.474|
|[[:human genes:c:c19orf53|C19orf53]]|0.465|
|[[:human genes:t:tsr1|TSR1]]|0.448|
|[[:human genes:a:adrm1|ADRM1]]|0.41|
|[[:human genes:r:rpl27|RPL27]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPL18 Expression in NALM6 Cells: 8.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>