RPL26 [The Human Chemical-Genetic Interaction Map Project]

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======= RPL26 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPL26
  * **<color #00a2e8>Official Name</color>**: ribosomal protein L26
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6154|6154]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61254|P61254]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPL26&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPL26|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603704|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KOW|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|regulation of translation involved in cellular response to UV|
|regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|
|positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|
|positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|cytosolic ribosome|
|positive regulation of DNA damage response, signal transduction by p53 class mediator|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|positive regulation of signal transduction by p53 class mediator|
|mRNA 5-UTR binding|
|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|cellular response to gamma radiation|
|regulation of DNA damage response, signal transduction by p53 class mediator|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|response to gamma radiation|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|positive regulation of intrinsic apoptotic signaling pathway|
|mitotic G1 DNA damage checkpoint|
|mitotic G1/S transition checkpoint|
|G1 DNA damage checkpoint|
|cytosolic large ribosomal subunit|
|cellular response to ionizing radiation|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in cell cycle checkpoint|
|ribosomal large subunit biogenesis|
|cytoplasmic translation|
|DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cell cycle arrest|
|cellular response to UV|
|mitotic DNA damage checkpoint|
|SRP-dependent cotranslational protein targeting to membrane|
|positive regulation of response to DNA damage stimulus|
|cotranslational protein targeting to membrane|
|negative regulation of G1/S transition of mitotic cell cycle|
|mitotic DNA integrity checkpoint|
|signal transduction in response to DNA damage|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|cellular response to light stimulus|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|signal transduction by p53 class mediator|
|positive regulation of translation|
|viral gene expression|
|DNA damage checkpoint|
|protein localization to endoplasmic reticulum|
|translational initiation|
|response to UV|
|DNA integrity checkpoint|
|response to ionizing radiation|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of cellular amide metabolic process|
|mitotic cell cycle checkpoint|
|ribonucleoprotein complex|
|protein targeting to membrane|
|regulation of intrinsic apoptotic signaling pathway|
|regulation of cell cycle G1/S phase transition|
|structural constituent of ribosome|
|cellular response to radiation|
|positive regulation of apoptotic signaling pathway|
|regulation of signal transduction by p53 class mediator|
|cell cycle checkpoint|
|nuclear-transcribed mRNA catabolic process|
|negative regulation of mitotic cell cycle phase transition|
|rRNA processing|
|mRNA catabolic process|
|regulation of response to DNA damage stimulus|
|rRNA metabolic process|
|negative regulation of cell cycle phase transition|
|RNA catabolic process|
|establishment of protein localization to membrane|
|positive regulation of cell cycle process|
|ribosome biogenesis|
|response to light stimulus|
|negative regulation of mitotic cell cycle|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|negative regulation of cell cycle process|
|regulation of translation|
|protein targeting|
|nucleobase-containing compound catabolic process|
|positive regulation of cell cycle|
|translation|
|ncRNA processing|
|regulation of apoptotic signaling pathway|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|regulation of mitotic cell cycle phase transition|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|response to radiation|
|aromatic compound catabolic process|
|regulation of cell cycle phase transition|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|mitotic cell cycle|
|mRNA metabolic process|
|positive regulation of cell death|
|viral process|
|regulation of cellular response to stress|
|protein localization to organelle|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|nucleolus|
|RNA processing|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|cell cycle process|
|positive regulation of intracellular signal transduction|
|macromolecule catabolic process|
|response to abiotic stimulus|
|regulation of cell cycle|
|cell cycle|
|RNA binding|
|organonitrogen compound biosynthetic process|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.74|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.77|
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.83|
|[[:results:exp303|39°C R06 exp303]]|1.85|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.85|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|1.96|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:supt6h|SUPT6H]]|0.46|
|[[:human genes:p:psmd1|PSMD1]]|0.46|
|[[:human genes:p:psmc1|PSMC1]]|0.454|
|[[:human genes:p:polr2j3|POLR2J3]]|0.453|
|[[:human genes:m:mt1e|MT1E]]|0.448|
|[[:human genes:e:exd1|EXD1]]|0.446|
|[[:human genes:t:ticrr|TICRR]]|0.441|
|[[:human genes:c:cep192|CEP192]]|0.43|
|[[:human genes:n:nupl1|NUPL1]]|0.426|
|[[:human genes:c:cdca3|CDCA3]]|0.424|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.422|
|[[:human genes:r:rpl14|RPL14]]|0.422|
|[[:human genes:r:rpl34|RPL34]]|0.42|
|[[:human genes:r:rrp15|RRP15]]|0.42|
|[[:human genes:c:ccna2|CCNA2]]|0.418|
|[[:human genes:c:cbwd5|CBWD5]]|0.418|
|[[:human genes:d:dtl|DTL]]|0.416|
|[[:human genes:n:nol12|NOL12]]|0.409|
|[[:human genes:c:copb1|COPB1]]|0.404|
|[[:human genes:t:terf1|TERF1]]|0.402|
|[[:human genes:r:rrm1|RRM1]]|0.401|
|[[:human genes:d:dnajc16|DNAJC16]]|0.401|
|[[:human genes:r:rplp1|RPLP1]]|0.401|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 622/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|27/28|
|blood|23/28|
|bone|22/26|
|breast|30/33|
|central nervous system|44/56|
|cervix|3/4|
|colorectal|16/17|
|esophagus|10/13|
|fibroblast|0/1|
|gastric|13/16|
|kidney|14/21|
|liver|18/20|
|lung|59/75|
|lymphocyte|10/16|
|ovary|25/26|
|pancreas|22/24|
|peripheral nervous system|14/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|19/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|27/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 409
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPL26 Expression in NALM6 Cells: 8.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>