RPL34 [The Human Chemical-Genetic Interaction Map Project]

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======= RPL34 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPL34
  * **<color #00a2e8>Official Name</color>**: ribosomal protein L34
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6164|6164]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49207|P49207]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPL34&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPL34|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616862|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the large ribosomal subunit. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000305|PubMed:12962325}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L34e|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytosolic large ribosomal subunit|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|establishment of protein localization to membrane|
|cadherin binding|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|peptide biosynthetic process|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|endoplasmic reticulum|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.46|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.16|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.07|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.06|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.87|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.74|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.73|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.72|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|1.71|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.74|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.75|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.76|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.77|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.79|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.81|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.82|
|[[:results:exp132|Metformin 40μM R03 exp132]]|1.82|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|1.89|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.9|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|1.92|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.97|
|[[:results:exp187|proTAME 5μM R04 exp187]]|2.01|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|2.02|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.13|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2.28|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|2.4|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|2.68|
|[[:results:exp115|A-366 10μM R03 exp115]]|2.69|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.508|
|[[:human genes:r:rpl35|RPL35]]|0.507|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.499|
|[[:human genes:z:znf655|ZNF655]]|0.497|
|[[:human genes:r:rpl38|RPL38]]|0.494|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.493|
|[[:human genes:o:orc1|ORC1]]|0.487|
|[[:human genes:r:rpl30|RPL30]]|0.482|
|[[:human genes:p:psmb4|PSMB4]]|0.48|
|[[:human genes:d:ddtl|DDTL]]|0.479|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.476|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.476|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.476|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.475|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.473|
|[[:human genes:c:cep192|CEP192]]|0.472|
|[[:human genes:p:psma6|PSMA6]]|0.471|
|[[:human genes:t:tfip11|TFIP11]]|0.467|
|[[:human genes:c:c14orf93|C14orf93]]|0.467|
|[[:human genes:p:polr2j3|POLR2J3]]|0.464|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.464|
|[[:human genes:o:orc6|ORC6]]|0.463|
|[[:human genes:r:rpl9|RPL9]]|0.463|
|[[:human genes:r:rps12|RPS12]]|0.462|
|[[:human genes:w:wdr43|WDR43]]|0.461|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.459|
|[[:human genes:c:ccdc94|CCDC94]]|0.459|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.457|
|[[:human genes:f:fam160a1|FAM160A1]]|0.457|
|[[:human genes:c:cbwd3|CBWD3]]|0.457|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.457|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.456|
|[[:human genes:r:rpl17|RPL17]]|0.455|
|[[:human genes:c:copb1|COPB1]]|0.453|
|[[:human genes:s:syt9|SYT9]]|0.45|
|[[:human genes:e:exosc3|EXOSC3]]|0.45|
|[[:human genes:c:cbwd5|CBWD5]]|0.45|
|[[:human genes:r:rad51|RAD51]]|0.448|
|[[:human genes:c:cactin|CACTIN]]|0.447|
|[[:human genes:t:tceb3c|TCEB3C]]|0.447|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.447|
|[[:human genes:n:nol10|NOL10]]|0.446|
|[[:human genes:o:osbp|OSBP]]|0.445|
|[[:human genes:n:nupl1|NUPL1]]|0.444|
|[[:human genes:t:ticrr|TICRR]]|0.444|
|[[:human genes:r:rrp15|RRP15]]|0.443|
|[[:human genes:t:twistnb|TWISTNB]]|0.442|
|[[:human genes:a:ankle1|ANKLE1]]|0.442|
|[[:human genes:m:mki67ip|MKI67IP]]|0.441|
|[[:human genes:c:copz1|COPZ1]]|0.44|
|[[:human genes:r:rpl6|RPL6]]|0.439|
|[[:human genes:a:atp6ap2|ATP6AP2]]|0.437|
|[[:human genes:d:ddt|DDT]]|0.436|
|[[:human genes:c:cbwd6|CBWD6]]|0.436|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.435|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.435|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.435|
|[[:human genes:w:wdr87|WDR87]]|0.435|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.432|
|[[:human genes:t:tspy8|TSPY8]]|0.432|
|[[:human genes:z:znf830|ZNF830]]|0.431|
|[[:human genes:z:zfand5|ZFAND5]]|0.43|
|[[:human genes:a:arcn1|ARCN1]]|0.43|
|[[:human genes:r:rrn3|RRN3]]|0.429|
|[[:human genes:r:riok2|RIOK2]]|0.429|
|[[:human genes:k:kctd17|KCTD17]]|0.428|
|[[:human genes:r:rps2|RPS2]]|0.428|
|[[:human genes:c:chd4|CHD4]]|0.428|
|[[:human genes:s:supt5h|SUPT5H]]|0.428|
|[[:human genes:r:rpl14|RPL14]]|0.427|
|[[:human genes:c:copb2|COPB2]]|0.425|
|[[:human genes:s:snrpa1|SNRPA1]]|0.425|
|[[:human genes:b:brix1|BRIX1]]|0.425|
|[[:human genes:p:psmd3|PSMD3]]|0.425|
|[[:human genes:n:nbpf10|NBPF10]]|0.423|
|[[:human genes:t:top1mt|TOP1MT]]|0.423|
|[[:human genes:c:col2a1|COL2A1]]|0.423|
|[[:human genes:f:fcn2|FCN2]]|0.421|
|[[:human genes:s:supt6h|SUPT6H]]|0.421|
|[[:human genes:v:vasn|VASN]]|0.421|
|[[:human genes:r:rpl26|RPL26]]|0.42|
|[[:human genes:o:or10g3|OR10G3]]|0.419|
|[[:human genes:p:psmb1|PSMB1]]|0.418|
|[[:human genes:c:cdc73|CDC73]]|0.417|
|[[:human genes:c:copg1|COPG1]]|0.417|
|[[:human genes:p:pcf11|PCF11]]|0.416|
|[[:human genes:s:sf3b1|SF3B1]]|0.414|
|[[:human genes:p:psmd1|PSMD1]]|0.413|
|[[:human genes:v:vps28|VPS28]]|0.412|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.412|
|[[:human genes:m:mt1e|MT1E]]|0.412|
|[[:human genes:r:rrp1|RRP1]]|0.412|
|[[:human genes:s:slc4a1|SLC4A1]]|0.411|
|[[:human genes:b:bysl|BYSL]]|0.41|
|[[:human genes:c:cdc6|CDC6]]|0.409|
|[[:human genes:s:ssh2|SSH2]]|0.409|
|[[:human genes:r:rps28|RPS28]]|0.408|
|[[:human genes:r:rnf113a|RNF113A]]|0.407|
|[[:human genes:r:rbm39|RBM39]]|0.407|
|[[:human genes:p:psmb2|PSMB2]]|0.406|
|[[:human genes:s:sap30bp|SAP30BP]]|0.405|
|[[:human genes:n:nol9|NOL9]]|0.405|
|[[:human genes:k:krt78|KRT78]]|0.405|
|[[:human genes:r:ranbp2|RANBP2]]|0.404|
|[[:human genes:p:ppie|PPIE]]|0.403|
|[[:human genes:c:cdc45|CDC45]]|0.403|
|[[:human genes:p:psma7|PSMA7]]|0.402|
|[[:human genes:f:fbxw9|FBXW9]]|0.4|
|[[:human genes:p:psmc6|PSMC6]]|0.4|
|[[:human genes:p:psmc1|PSMC1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 260/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|6/28|
|blood|10/28|
|bone|6/26|
|breast|6/33|
|central nervous system|20/56|
|cervix|2/4|
|colorectal|10/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|10/21|
|liver|10/20|
|lung|27/75|
|lymphocyte|8/16|
|ovary|10/26|
|pancreas|7/24|
|peripheral nervous system|4/16|
|plasma cell|8/15|
|prostate|0/1|
|skin|12/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|8/22|
|urinary tract|11/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 886
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.85 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPL34 Expression in NALM6 Cells: 7.85'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>