RPN2 [The Human Chemical-Genetic Interaction Map Project]

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======= RPN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPN2
  * **<color #00a2e8>Official Name</color>**: ribophorin II
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6185|6185]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04844|P04844]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180490|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. {ECO:0000250|UniProtKB:F1PCT7, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribophorin II|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dolichyl-diphosphooligosaccharide-protein glycotransferase activity|
|oligosaccharyltransferase complex|
|autophagosome membrane|
|protein N-linked glycosylation via asparagine|
|peptidyl-asparagine modification|
|ribosome binding|
|rough endoplasmic reticulum|
|protein N-linked glycosylation|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|aging|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|carbohydrate derivative biosynthetic process|
|peptidyl-amino acid modification|
|endoplasmic reticulum membrane|
|response to drug|
|carbohydrate derivative metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.7|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.73|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|2.18|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|2.29|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|2.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rpn1|RPN1]]|0.472|
|[[:human genes:d:ddost|DDOST]]|0.463|
|[[:human genes:s:sec61b|SEC61B]]|0.431|
|[[:human genes:d:dad1|DAD1]]|0.427|
|[[:human genes:o:ost4|OST4]]|0.409|
|[[:human genes:t:tmem258|TMEM258]]|0.403|
|[[:human genes:s:sec63|SEC63]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 301/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|15/28|
|blood|10/28|
|bone|13/26|
|breast|13/33|
|central nervous system|16/56|
|cervix|0/4|
|colorectal|5/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|6/16|
|kidney|8/21|
|liver|12/20|
|lung|32/75|
|lymphocyte|6/16|
|ovary|11/26|
|pancreas|9/24|
|peripheral nervous system|4/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|9/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|17/22|
|urinary tract|12/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 598
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPN2 Expression in NALM6 Cells: 8.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>