RPP21 [The Human Chemical-Genetic Interaction Map Project]

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======= RPP21 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPP21
  * **<color #00a2e8>Official Name</color>**: ribonuclease P/MRP subunit p21
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79897|79897]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H633|Q9H633]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPP21&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPP21|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612524|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rpr2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleolar ribonuclease P complex|
|ribonuclease P RNA binding|
|multimeric ribonuclease P complex|
|ribonuclease P activity|
|tRNA 5-leader removal|
|tRNA 5-end processing|
|ncRNA 5-end processing|
|RNA 5-end processing|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|tRNA processing|
|RNA phosphodiester bond hydrolysis|
|tRNA metabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|ncRNA processing|
|ncRNA metabolic process|
|RNA processing|
|response to drug|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.96|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2.31|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-2.12|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.1|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.89|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-1.84|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.8|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.78|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-1.77|
|[[:results:exp218|A-395 10μM R05 exp218]]|-1.74|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-1.74|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-1.7|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.7|
|[[:results:exp539|42°C R08 exp539]]|1.78|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.84|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.9|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.91|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.07|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.07|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.07|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.09|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.16|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.64|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.75|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.704|
|[[:human genes:a:alg1|ALG1]]|0.642|
|[[:human genes:g:gmppb|GMPPB]]|0.636|
|[[:human genes:a:adsl|ADSL]]|0.627|
|[[:human genes:p:pmm2|PMM2]]|0.619|
|[[:human genes:e:exoc4|EXOC4]]|0.614|
|[[:human genes:r:rtcb|RTCB]]|0.613|
|[[:human genes:o:osgep|OSGEP]]|0.61|
|[[:human genes:t:tsen54|TSEN54]]|0.603|
|[[:human genes:u:uap1|UAP1]]|0.595|
|[[:human genes:v:vezt|VEZT]]|0.595|
|[[:human genes:g:gemin8|GEMIN8]]|0.594|
|[[:human genes:d:dpagt1|DPAGT1]]|0.594|
|[[:human genes:g:gnb1l|GNB1L]]|0.588|
|[[:human genes:r:rnmt|RNMT]]|0.587|
|[[:human genes:g:gemin6|GEMIN6]]|0.586|
|[[:human genes:n:nae1|NAE1]]|0.579|
|[[:human genes:d:ddx20|DDX20]]|0.577|
|[[:human genes:g:gfpt1|GFPT1]]|0.574|
|[[:human genes:u:utp23|UTP23]]|0.573|
|[[:human genes:t:ten1|TEN1]]|0.565|
|[[:human genes:u:uhrf1|UHRF1]]|0.56|
|[[:human genes:a:atxn10|ATXN10]]|0.56|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.558|
|[[:human genes:e:elp2|ELP2]]|0.555|
|[[:human genes:s:ssb|SSB]]|0.554|
|[[:human genes:u:urm1|URM1]]|0.552|
|[[:human genes:g:gemin7|GEMIN7]]|0.55|
|[[:human genes:t:telo2|TELO2]]|0.546|
|[[:human genes:r:rptor|RPTOR]]|0.546|
|[[:human genes:r:rpia|RPIA]]|0.545|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.544|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.54|
|[[:human genes:a:alg13|ALG13]]|0.54|
|[[:human genes:t:tti2|TTI2]]|0.54|
|[[:human genes:r:rft1|RFT1]]|0.539|
|[[:human genes:z:zrsr2|ZRSR2]]|0.539|
|[[:human genes:e:elp3|ELP3]]|0.536|
|[[:human genes:m:msto1|MSTO1]]|0.535|
|[[:human genes:d:dr1|DR1]]|0.531|
|[[:human genes:p:ppcs|PPCS]]|0.525|
|[[:human genes:r:rpe|RPE]]|0.523|
|[[:human genes:t:tbcb|TBCB]]|0.522|
|[[:human genes:f:fh|FH]]|0.522|
|[[:human genes:e:eprs|EPRS]]|0.52|
|[[:human genes:c:cep57|CEP57]]|0.518|
|[[:human genes:d:dohh|DOHH]]|0.518|
|[[:human genes:t:trmt5|TRMT5]]|0.517|
|[[:human genes:m:med16|MED16]]|0.517|
|[[:human genes:t:triap1|TRIAP1]]|0.515|
|[[:human genes:a:alg2|ALG2]]|0.514|
|[[:human genes:y:yars|YARS]]|0.514|
|[[:human genes:r:rabggtb|RABGGTB]]|0.511|
|[[:human genes:t:tprkb|TPRKB]]|0.509|
|[[:human genes:s:srp14|SRP14]]|0.508|
|[[:human genes:p:ppp4c|PPP4C]]|0.508|
|[[:human genes:e:exoc3|EXOC3]]|0.508|
|[[:human genes:p:ppp6c|PPP6C]]|0.507|
|[[:human genes:d:dolk|DOLK]]|0.505|
|[[:human genes:t:ttc4|TTC4]]|0.504|
|[[:human genes:g:gemin5|GEMIN5]]|0.504|
|[[:human genes:t:tsen34|TSEN34]]|0.503|
|[[:human genes:p:polr3h|POLR3H]]|0.501|
|[[:human genes:r:rad1|RAD1]]|0.501|
|[[:human genes:a:atp5o|ATP5O]]|0.5|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.497|
|[[:human genes:e:ercc2|ERCC2]]|0.496|
|[[:human genes:a:atp5j|ATP5J]]|0.493|
|[[:human genes:f:fnta|FNTA]]|0.493|
|[[:human genes:d:ddx1|DDX1]]|0.489|
|[[:human genes:c:ctc1|CTC1]]|0.488|
|[[:human genes:r:rfk|RFK]]|0.486|
|[[:human genes:p:pelo|PELO]]|0.484|
|[[:human genes:s:slc25a19|SLC25A19]]|0.483|
|[[:human genes:t:tamm41|TAMM41]]|0.482|
|[[:human genes:t:trnt1|TRNT1]]|0.481|
|[[:human genes:s:snapc5|SNAPC5]]|0.48|
|[[:human genes:c:ccdc101|CCDC101]]|0.48|
|[[:human genes:u:uxt|UXT]]|0.48|
|[[:human genes:k:kdm8|KDM8]]|0.479|
|[[:human genes:t:tti1|TTI1]]|0.479|
|[[:human genes:l:lsm10|LSM10]]|0.479|
|[[:human genes:a:alg6|ALG6]]|0.477|
|[[:human genes:f:fen1|FEN1]]|0.477|
|[[:human genes:w:wdr92|WDR92]]|0.476|
|[[:human genes:e:elac2|ELAC2]]|0.474|
|[[:human genes:a:atp5b|ATP5B]]|0.474|
|[[:human genes:t:txnrd1|TXNRD1]]|0.473|
|[[:human genes:h:hspd1|HSPD1]]|0.472|
|[[:human genes:s:srpk1|SRPK1]]|0.471|
|[[:human genes:t:txnl4b|TXNL4B]]|0.469|
|[[:human genes:d:ddx55|DDX55]]|0.469|
|[[:human genes:e:elp6|ELP6]]|0.467|
|[[:human genes:e:eef1e1|EEF1E1]]|0.467|
|[[:human genes:d:dhrsx|DHRSX]]|0.466|
|[[:human genes:n:naf1|NAF1]]|0.466|
|[[:human genes:t:trmt61a|TRMT61A]]|0.465|
|[[:human genes:l:lsm11|LSM11]]|0.464|
|[[:human genes:n:nhp2|NHP2]]|0.464|
|[[:human genes:d:dhps|DHPS]]|0.462|
|[[:human genes:c:c15orf41|C15orf41]]|0.462|
|[[:human genes:v:vrk1|VRK1]]|0.461|
|[[:human genes:r:rnaseh2b|RNASEH2B]]|0.457|
|[[:human genes:d:dctn6|DCTN6]]|0.453|
|[[:human genes:n:nsmce1|NSMCE1]]|0.452|
|[[:human genes:e:eny2|ENY2]]|0.452|
|[[:human genes:d:ddx39a|DDX39A]]|0.451|
|[[:human genes:t:tpk1|TPK1]]|0.451|
|[[:human genes:t:tmem41b|TMEM41B]]|0.451|
|[[:human genes:g:gpn2|GPN2]]|0.45|
|[[:human genes:a:alg14|ALG14]]|0.45|
|[[:human genes:t:timm22|TIMM22]]|0.45|
|[[:human genes:s:spr|SPR]]|0.45|
|[[:human genes:p:pdap1|PDAP1]]|0.45|
|[[:human genes:s:sugt1|SUGT1]]|0.447|
|[[:human genes:s:sgol1|SGOL1]]|0.445|
|[[:human genes:p:ppcdc|PPCDC]]|0.445|
|[[:human genes:e:eftud1|EFTUD1]]|0.445|
|[[:human genes:p:ptar1|PTAR1]]|0.444|
|[[:human genes:e:eif3f|EIF3F]]|0.444|
|[[:human genes:u:ube2g2|UBE2G2]]|0.444|
|[[:human genes:m:med4|MED4]]|0.443|
|[[:human genes:d:dad1|DAD1]]|0.443|
|[[:human genes:f:fbxw7|FBXW7]]|0.442|
|[[:human genes:a:atp5a1|ATP5A1]]|0.441|
|[[:human genes:c:ctu1|CTU1]]|0.439|
|[[:human genes:p:pggt1b|PGGT1B]]|0.439|
|[[:human genes:c:c1d|C1D]]|0.437|
|[[:human genes:a:aars|AARS]]|0.434|
|[[:human genes:f:fntb|FNTB]]|0.433|
|[[:human genes:d:ddost|DDOST]]|0.433|
|[[:human genes:a:atic|ATIC]]|0.433|
|[[:human genes:t:taf1a|TAF1A]]|0.433|
|[[:human genes:h:haus8|HAUS8]]|0.433|
|[[:human genes:s:slc25a26|SLC25A26]]|0.431|
|[[:human genes:s:snf8|SNF8]]|0.431|
|[[:human genes:m:mocs3|MOCS3]]|0.43|
|[[:human genes:c:cxorf56|CXorf56]]|0.43|
|[[:human genes:c:cdipt|CDIPT]]|0.43|
|[[:human genes:m:mettl14|METTL14]]|0.429|
|[[:human genes:c:c14orf80|C14orf80]]|0.429|
|[[:human genes:w:wdr82|WDR82]]|0.428|
|[[:human genes:n:naa20|NAA20]]|0.428|
|[[:human genes:t:trmt10a|TRMT10A]]|0.427|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.425|
|[[:human genes:o:oraov1|ORAOV1]]|0.424|
|[[:human genes:c:cbfb|CBFB]]|0.424|
|[[:human genes:t:tgs1|TGS1]]|0.423|
|[[:human genes:s:sec61g|SEC61G]]|0.423|
|[[:human genes:a:atrx|ATRX]]|0.422|
|[[:human genes:c:chchd4|CHCHD4]]|0.421|
|[[:human genes:p:pgm3|PGM3]]|0.42|
|[[:human genes:e:elp4|ELP4]]|0.419|
|[[:human genes:z:znhit1|ZNHIT1]]|0.419|
|[[:human genes:t:tbca|TBCA]]|0.418|
|[[:human genes:w:wdr59|WDR59]]|0.418|
|[[:human genes:c:c14orf166|C14orf166]]|0.418|
|[[:human genes:b:bap1|BAP1]]|0.418|
|[[:human genes:s:sdha|SDHA]]|0.417|
|[[:human genes:d:dicer1|DICER1]]|0.417|
|[[:human genes:u:uba3|UBA3]]|0.417|
|[[:human genes:c:csnk2b|CSNK2B]]|0.416|
|[[:human genes:p:paxip1|PAXIP1]]|0.416|
|[[:human genes:a:alg5|ALG5]]|0.415|
|[[:human genes:k:kdsr|KDSR]]|0.414|
|[[:human genes:s:sec62|SEC62]]|0.413|
|[[:human genes:z:zbtb11|ZBTB11]]|0.412|
|[[:human genes:t:tmem242|TMEM242]]|0.412|
|[[:human genes:e:eif4e|EIF4E]]|0.412|
|[[:human genes:c:crcp|CRCP]]|0.412|
|[[:human genes:b:bub3|BUB3]]|0.411|
|[[:human genes:s:spcs2|SPCS2]]|0.41|
|[[:human genes:d:dpf2|DPF2]]|0.41|
|[[:human genes:c:cct7|CCT7]]|0.41|
|[[:human genes:n:nars|NARS]]|0.409|
|[[:human genes:c:ciao1|CIAO1]]|0.409|
|[[:human genes:a:atp5d|ATP5D]]|0.408|
|[[:human genes:i:ipo9|IPO9]]|0.407|
|[[:human genes:e:eif1ax|EIF1AX]]|0.407|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.407|
|[[:human genes:t:thoc3|THOC3]]|0.407|
|[[:human genes:d:dnlz|DNLZ]]|0.406|
|[[:human genes:r:rad50|RAD50]]|0.406|
|[[:human genes:s:srd5a3|SRD5A3]]|0.405|
|[[:human genes:n:nbn|NBN]]|0.405|
|[[:human genes:p:pam16|PAM16]]|0.404|
|[[:human genes:s:sbds|SBDS]]|0.403|
|[[:human genes:v:vhl|VHL]]|0.402|
|[[:human genes:g:gtf3c5|GTF3C5]]|0.4|
|[[:human genes:b:bcs1l|BCS1L]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 729/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|25/26|
|breast|31/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|0/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 122
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPP21 Expression in NALM6 Cells: 4.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>