RPP40 [The Human Chemical-Genetic Interaction Map Project]

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======= RPP40 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPP40
  * **<color #00a2e8>Official Name</color>**: ribonuclease P/MRP subunit p40
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10799|10799]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75818|O75818]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPP40&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPP40|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606117|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribonuc P 40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleolar ribonuclease P complex|
|ribonuclease P RNA binding|
|multimeric ribonuclease P complex|
|ribonuclease P activity|
|tRNA 5-leader removal|
|tRNA 5-end processing|
|ncRNA 5-end processing|
|RNA 5-end processing|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|tRNA processing|
|RNA phosphodiester bond hydrolysis|
|tRNA metabolic process|
|rRNA processing|
|rRNA metabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|RNA processing|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.614|
|[[:human genes:o:orc6|ORC6]]|0.427|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.427|
|[[:human genes:s:slc6a17|SLC6A17]]|0.421|
|[[:human genes:u:utp3|UTP3]]|0.419|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.416|
|[[:human genes:s:supt5h|SUPT5H]]|0.413|
|[[:human genes:l:lrrc56|LRRC56]]|0.405|
|[[:human genes:n:narfl|NARFL]]|0.405|
|[[:human genes:u:upf1|UPF1]]|0.402|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.402|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 692/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|25/28|
|bone|25/26|
|breast|28/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|21/21|
|liver|17/20|
|lung|69/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|13/15|
|prostate|0/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1157
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPP40 Expression in NALM6 Cells: 4.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>