RPS11 [The Human Chemical-Genetic Interaction Map Project]

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======= RPS11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPS11
  * **<color #00a2e8>Official Name</color>**: ribosomal protein S11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6205|6205]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62280|P62280]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPS11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPS11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180471|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S17|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rRNA binding|
|ribosome|
|cytosolic small ribosomal subunit|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|establishment of protein localization to membrane|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|protein localization to membrane|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|nucleolus|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-2.95|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.29|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-2.26|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-2.24|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-2.24|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.92|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.91|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.9|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.88|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.8|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.71|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.71|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|1.73|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.75|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.75|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.88|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.92|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.95|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.17|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|2.18|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2.44|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|2.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rps5|RPS5]]|0.534|
|[[:human genes:p:prim1|PRIM1]]|0.495|
|[[:human genes:r:rps16|RPS16]]|0.485|
|[[:human genes:r:rps7|RPS7]]|0.482|
|[[:human genes:r:rps28|RPS28]]|0.475|
|[[:human genes:r:rpl35|RPL35]]|0.472|
|[[:human genes:b:bysl|BYSL]]|0.471|
|[[:human genes:r:rps3a|RPS3A]]|0.456|
|[[:human genes:r:rps12|RPS12]]|0.452|
|[[:human genes:p:psmb4|PSMB4]]|0.451|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.442|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.442|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.441|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.441|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.437|
|[[:human genes:s:scaf1|SCAF1]]|0.436|
|[[:human genes:r:rbbp5|RBBP5]]|0.429|
|[[:human genes:k:kctd17|KCTD17]]|0.426|
|[[:human genes:p:psmb1|PSMB1]]|0.426|
|[[:human genes:a:adrm1|ADRM1]]|0.424|
|[[:human genes:m:myb|MYB]]|0.424|
|[[:human genes:n:nip7|NIP7]]|0.423|
|[[:human genes:d:ddx56|DDX56]]|0.422|
|[[:human genes:p:psma7|PSMA7]]|0.42|
|[[:human genes:n:nop16|NOP16]]|0.417|
|[[:human genes:s:sf3a1|SF3A1]]|0.417|
|[[:human genes:r:rps2|RPS2]]|0.415|
|[[:human genes:r:rpl14|RPL14]]|0.413|
|[[:human genes:n:nupl1|NUPL1]]|0.413|
|[[:human genes:u:utp20|UTP20]]|0.41|
|[[:human genes:p:psmb2|PSMB2]]|0.41|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.409|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.409|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.409|
|[[:human genes:t:ttk|TTK]]|0.408|
|[[:human genes:t:tceb3c|TCEB3C]]|0.408|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.407|
|[[:human genes:r:riok2|RIOK2]]|0.407|
|[[:human genes:p:pwp2|PWP2]]|0.406|
|[[:human genes:r:rps27a|RPS27A]]|0.405|
|[[:human genes:n:nol10|NOL10]]|0.403|
|[[:human genes:n:npipb8|NPIPB8]]|0.402|
|[[:human genes:i:incenp|INCENP]]|0.402|
|[[:human genes:l:lrr1|LRR1]]|0.4|
|[[:human genes:s:smc4|SMC4]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 738/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 468
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPS11 Expression in NALM6 Cells: 9.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>