RPS12 [The Human Chemical-Genetic Interaction Map Project]

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======= RPS12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPS12
  * **<color #00a2e8>Official Name</color>**: ribosomal protein S12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6206|6206]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25398|P25398]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPS12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPS12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603660|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L7Ae|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytosolic small ribosomal subunit|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|establishment of protein localization to membrane|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|peptide biosynthetic process|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|intracellular membrane-bounded organelle|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular macromolecule catabolic process|
|Golgi apparatus|
|intracellular protein transport|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-2.34|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.88|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.7|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.72|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.72|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.74|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.79|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.43|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.55|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|2.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:ddtl|DDTL]]|0.58|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.574|
|[[:human genes:t:tceb3c|TCEB3C]]|0.571|
|[[:human genes:r:rps2|RPS2]]|0.563|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.562|
|[[:human genes:t:tfip11|TFIP11]]|0.56|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.558|
|[[:human genes:n:nol10|NOL10]]|0.556|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.554|
|[[:human genes:p:psma6|PSMA6]]|0.552|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.549|
|[[:human genes:r:rps19|RPS19]]|0.542|
|[[:human genes:c:chd4|CHD4]]|0.541|
|[[:human genes:r:rps5|RPS5]]|0.535|
|[[:human genes:r:rbm39|RBM39]]|0.53|
|[[:human genes:t:tspy8|TSPY8]]|0.53|
|[[:human genes:r:rpl35|RPL35]]|0.528|
|[[:human genes:r:rps28|RPS28]]|0.528|
|[[:human genes:v:vasn|VASN]]|0.526|
|[[:human genes:r:rps3a|RPS3A]]|0.521|
|[[:human genes:c:cdc73|CDC73]]|0.518|
|[[:human genes:d:dtl|DTL]]|0.516|
|[[:human genes:p:psmb4|PSMB4]]|0.515|
|[[:human genes:r:rbbp5|RBBP5]]|0.514|
|[[:human genes:k:kctd17|KCTD17]]|0.511|
|[[:human genes:p:pcf11|PCF11]]|0.511|
|[[:human genes:n:nupl1|NUPL1]]|0.509|
|[[:human genes:r:rpl6|RPL6]]|0.508|
|[[:human genes:p:psmd11|PSMD11]]|0.508|
|[[:human genes:s:syt9|SYT9]]|0.505|
|[[:human genes:f:fam25b|FAM25B]]|0.504|
|[[:human genes:n:nol12|NOL12]]|0.503|
|[[:human genes:c:ccna2|CCNA2]]|0.503|
|[[:human genes:t:terf2|TERF2]]|0.502|
|[[:human genes:p:psmc6|PSMC6]]|0.5|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.499|
|[[:human genes:r:rps7|RPS7]]|0.499|
|[[:human genes:r:rps3|RPS3]]|0.499|
|[[:human genes:k:kif3c|KIF3C]]|0.498|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.498|
|[[:human genes:r:rps27a|RPS27A]]|0.498|
|[[:human genes:o:orc1|ORC1]]|0.498|
|[[:human genes:k:krt2|KRT2]]|0.497|
|[[:human genes:p:psmb1|PSMB1]]|0.497|
|[[:human genes:n:narfl|NARFL]]|0.496|
|[[:human genes:s:s1pr4|S1PR4]]|0.496|
|[[:human genes:n:nup133|NUP133]]|0.496|
|[[:human genes:p:psma7|PSMA7]]|0.494|
|[[:human genes:p:psmd1|PSMD1]]|0.492|
|[[:human genes:p:psmb2|PSMB2]]|0.491|
|[[:human genes:t:twistnb|TWISTNB]]|0.491|
|[[:human genes:t:terf1|TERF1]]|0.49|
|[[:human genes:p:ppfia4|PPFIA4]]|0.489|
|[[:human genes:x:xab2|XAB2]]|0.488|
|[[:human genes:p:psmd3|PSMD3]]|0.488|
|[[:human genes:a:aatf|AATF]]|0.486|
|[[:human genes:h:hivep3|HIVEP3]]|0.485|
|[[:human genes:z:znf106|ZNF106]]|0.485|
|[[:human genes:e:eif3g|EIF3G]]|0.485|
|[[:human genes:s:slc6a17|SLC6A17]]|0.485|
|[[:human genes:z:znf830|ZNF830]]|0.485|
|[[:human genes:r:rpl30|RPL30]]|0.485|
|[[:human genes:o:ogfr|OGFR]]|0.484|
|[[:human genes:i:ik|IK]]|0.483|
|[[:human genes:r:rplp1|RPLP1]]|0.483|
|[[:human genes:c:cbwd5|CBWD5]]|0.482|
|[[:human genes:m:mt1e|MT1E]]|0.479|
|[[:human genes:d:ddt|DDT]]|0.479|
|[[:human genes:c:cdc45|CDC45]]|0.479|
|[[:human genes:a:akirin2|AKIRIN2]]|0.478|
|[[:human genes:g:golga8o|GOLGA8O]]|0.478|
|[[:human genes:p:pola1|POLA1]]|0.478|
|[[:human genes:c:chchd3|CHCHD3]]|0.477|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.477|
|[[:human genes:c:copg1|COPG1]]|0.476|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.475|
|[[:human genes:n:nfatc4|NFATC4]]|0.475|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.475|
|[[:human genes:z:zfand5|ZFAND5]]|0.475|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.475|
|[[:human genes:r:rrp7a|RRP7A]]|0.475|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.475|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.475|
|[[:human genes:n:nop16|NOP16]]|0.473|
|[[:human genes:a:aqr|AQR]]|0.472|
|[[:human genes:a:akt1s1|AKT1S1]]|0.471|
|[[:human genes:c:cbwd3|CBWD3]]|0.47|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.47|
|[[:human genes:c:cactin|CACTIN]]|0.47|
|[[:human genes:c:c14orf93|C14orf93]]|0.469|
|[[:human genes:x:xylt2|XYLT2]]|0.468|
|[[:human genes:b:bysl|BYSL]]|0.468|
|[[:human genes:c:cdca3|CDCA3]]|0.467|
|[[:human genes:p:polr2f|POLR2F]]|0.467|
|[[:human genes:c:cdc6|CDC6]]|0.466|
|[[:human genes:p:psmc2|PSMC2]]|0.466|
|[[:human genes:t:top1mt|TOP1MT]]|0.466|
|[[:human genes:r:rps10|RPS10]]|0.465|
|[[:human genes:d:dimt1|DIMT1]]|0.464|
|[[:human genes:s:snip1|SNIP1]]|0.464|
|[[:human genes:i:iscu|ISCU]]|0.463|
|[[:human genes:s:scaf1|SCAF1]]|0.462|
|[[:human genes:u:utp20|UTP20]]|0.462|
|[[:human genes:r:rpl34|RPL34]]|0.462|
|[[:human genes:w:wdr87|WDR87]]|0.462|
|[[:human genes:c:cope|COPE]]|0.461|
|[[:human genes:c:ccdc116|CCDC116]]|0.461|
|[[:human genes:r:rnpc3|RNPC3]]|0.461|
|[[:human genes:o:orc6|ORC6]]|0.46|
|[[:human genes:p:polr2d|POLR2D]]|0.46|
|[[:human genes:n:npipb5|NPIPB5]]|0.46|
|[[:human genes:n:nup54|NUP54]]|0.459|
|[[:human genes:m:madcam1|MADCAM1]]|0.459|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.459|
|[[:human genes:c:ckap5|CKAP5]]|0.458|
|[[:human genes:p:psmc5|PSMC5]]|0.457|
|[[:human genes:h:hap1|HAP1]]|0.457|
|[[:human genes:g:golga8j|GOLGA8J]]|0.456|
|[[:human genes:m:msh5|MSH5]]|0.456|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.455|
|[[:human genes:p:psmd2|PSMD2]]|0.453|
|[[:human genes:r:rps11|RPS11]]|0.452|
|[[:human genes:t:timeless|TIMELESS]]|0.45|
|[[:human genes:t:ticrr|TICRR]]|0.45|
|[[:human genes:c:cwc22|CWC22]]|0.449|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.448|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.448|
|[[:human genes:m:mfsd12|MFSD12]]|0.448|
|[[:human genes:d:disp2|DISP2]]|0.448|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.447|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.447|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.446|
|[[:human genes:n:nsf|NSF]]|0.446|
|[[:human genes:m:myb|MYB]]|0.445|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.445|
|[[:human genes:c:cmya5|CMYA5]]|0.445|
|[[:human genes:w:wdr75|WDR75]]|0.445|
|[[:human genes:s:sf3a3|SF3A3]]|0.445|
|[[:human genes:s:ssh2|SSH2]]|0.445|
|[[:human genes:l:lrr1|LRR1]]|0.444|
|[[:human genes:s:snrpa1|SNRPA1]]|0.444|
|[[:human genes:w:wdr43|WDR43]]|0.444|
|[[:human genes:c:cln6|CLN6]]|0.444|
|[[:human genes:h:hnrnpc|HNRNPC]]|0.444|
|[[:human genes:c:cdt1|CDT1]]|0.443|
|[[:human genes:c:ctage4|CTAGE4]]|0.443|
|[[:human genes:p:pole2|POLE2]]|0.442|
|[[:human genes:s:supt5h|SUPT5H]]|0.441|
|[[:human genes:p:psmd14|PSMD14]]|0.441|
|[[:human genes:r:rrp1|RRP1]]|0.441|
|[[:human genes:p:plk4|PLK4]]|0.441|
|[[:human genes:t:traip|TRAIP]]|0.44|
|[[:human genes:r:rps9|RPS9]]|0.44|
|[[:human genes:s:sec13|SEC13]]|0.44|
|[[:human genes:i:igfn1|IGFN1]]|0.44|
|[[:human genes:p:psmc1|PSMC1]]|0.439|
|[[:human genes:r:rfc1|RFC1]]|0.439|
|[[:human genes:m:mcoln1|MCOLN1]]|0.439|
|[[:human genes:c:cep192|CEP192]]|0.438|
|[[:human genes:p:pole|POLE]]|0.437|
|[[:human genes:n:npipb8|NPIPB8]]|0.437|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.436|
|[[:human genes:p:plekha4|PLEKHA4]]|0.434|
|[[:human genes:p:polr2l|POLR2L]]|0.434|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.433|
|[[:human genes:m:myo1h|MYO1H]]|0.433|
|[[:human genes:r:rps14|RPS14]]|0.433|
|[[:human genes:e:eif3a|EIF3A]]|0.433|
|[[:human genes:r:rrp12|RRP12]]|0.433|
|[[:human genes:n:nbpf10|NBPF10]]|0.433|
|[[:human genes:n:nup98|NUP98]]|0.433|
|[[:human genes:c:cbwd6|CBWD6]]|0.432|
|[[:human genes:u:usp36|USP36]]|0.432|
|[[:human genes:g:gar1|GAR1]]|0.431|
|[[:human genes:p:paf1|PAF1]]|0.43|
|[[:human genes:n:napa|NAPA]]|0.43|
|[[:human genes:s:sf3a1|SF3A1]]|0.43|
|[[:human genes:a:acsf2|ACSF2]]|0.429|
|[[:human genes:a:ankle1|ANKLE1]]|0.429|
|[[:human genes:r:rps16|RPS16]]|0.429|
|[[:human genes:s:supt6h|SUPT6H]]|0.428|
|[[:human genes:m:myt1l|MYT1L]]|0.428|
|[[:human genes:e:exd1|EXD1]]|0.428|
|[[:human genes:p:pola2|POLA2]]|0.427|
|[[:human genes:g:gga3|GGA3]]|0.427|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.426|
|[[:human genes:c:chaf1a|CHAF1A]]|0.426|
|[[:human genes:d:ddx56|DDX56]]|0.426|
|[[:human genes:d:diexf|DIEXF]]|0.425|
|[[:human genes:z:znf574|ZNF574]]|0.425|
|[[:human genes:s:sfpq|SFPQ]]|0.425|
|[[:human genes:p:prpf8|PRPF8]]|0.425|
|[[:human genes:r:rnf113a|RNF113A]]|0.424|
|[[:human genes:u:upf1|UPF1]]|0.424|
|[[:human genes:a:ahctf1|AHCTF1]]|0.423|
|[[:human genes:r:ranbp2|RANBP2]]|0.423|
|[[:human genes:r:rilpl2|RILPL2]]|0.422|
|[[:human genes:c:casc3|CASC3]]|0.422|
|[[:human genes:n:nop14|NOP14]]|0.421|
|[[:human genes:f:fam160a1|FAM160A1]]|0.42|
|[[:human genes:m:med12|MED12]]|0.42|
|[[:human genes:e:elmod3|ELMOD3]]|0.419|
|[[:human genes:e:exosc3|EXOSC3]]|0.419|
|[[:human genes:t:taf12|TAF12]]|0.419|
|[[:human genes:s:smg1|SMG1]]|0.419|
|[[:human genes:m:mdm2|MDM2]]|0.419|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.419|
|[[:human genes:p:pdcd11|PDCD11]]|0.419|
|[[:human genes:u:utp3|UTP3]]|0.419|
|[[:human genes:p:ppan|PPAN]]|0.418|
|[[:human genes:p:prim1|PRIM1]]|0.418|
|[[:human genes:m:mki67ip|MKI67IP]]|0.418|
|[[:human genes:v:vps28|VPS28]]|0.417|
|[[:human genes:s:slc4a1|SLC4A1]]|0.417|
|[[:human genes:t:tyms|TYMS]]|0.417|
|[[:human genes:r:rplp2|RPLP2]]|0.416|
|[[:human genes:c:col2a1|COL2A1]]|0.415|
|[[:human genes:p:polr2h|POLR2H]]|0.415|
|[[:human genes:t:taf1|TAF1]]|0.415|
|[[:human genes:m:myh7b|MYH7B]]|0.414|
|[[:human genes:t:ttk|TTK]]|0.414|
|[[:human genes:s:srrm2|SRRM2]]|0.414|
|[[:human genes:a:acbd4|ACBD4]]|0.413|
|[[:human genes:g:gosr2|GOSR2]]|0.413|
|[[:human genes:e:exosc9|EXOSC9]]|0.413|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.412|
|[[:human genes:p:ppm1d|PPM1D]]|0.412|
|[[:human genes:s:sap30bp|SAP30BP]]|0.412|
|[[:human genes:t:tgm5|TGM5]]|0.412|
|[[:human genes:r:rpsa|RPSA]]|0.412|
|[[:human genes:b:brix1|BRIX1]]|0.412|
|[[:human genes:r:rffl|RFFL]]|0.412|
|[[:human genes:c:cyb561a3|CYB561A3]]|0.412|
|[[:human genes:r:rfxank|RFXANK]]|0.411|
|[[:human genes:e:eif2ak4|EIF2AK4]]|0.411|
|[[:human genes:r:rpl14|RPL14]]|0.41|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.41|
|[[:human genes:r:rad21|RAD21]]|0.41|
|[[:human genes:a:aamp|AAMP]]|0.41|
|[[:human genes:a:atxn1|ATXN1]]|0.409|
|[[:human genes:n:nup153|NUP153]]|0.409|
|[[:human genes:f:fbxw9|FBXW9]]|0.409|
|[[:human genes:n:nip7|NIP7]]|0.408|
|[[:human genes:n:nbpf16|NBPF16]]|0.408|
|[[:human genes:s:slc38a7|SLC38A7]]|0.408|
|[[:human genes:r:riok2|RIOK2]]|0.408|
|[[:human genes:t:tuba8|TUBA8]]|0.408|
|[[:human genes:e:eif4b|EIF4B]]|0.408|
|[[:human genes:g:golga6b|GOLGA6B]]|0.407|
|[[:human genes:g:golga8k|GOLGA8K]]|0.407|
|[[:human genes:f:foxd4l2|FOXD4L2]]|0.407|
|[[:human genes:c:ctr9|CTR9]]|0.407|
|[[:human genes:i:ints5|INTS5]]|0.406|
|[[:human genes:r:riok1|RIOK1]]|0.406|
|[[:human genes:e:egr2|EGR2]]|0.406|
|[[:human genes:r:rpl9|RPL9]]|0.405|
|[[:human genes:m:myt1|MYT1]]|0.405|
|[[:human genes:g:golga6a|GOLGA6A]]|0.405|
|[[:human genes:t:tpx2|TPX2]]|0.405|
|[[:human genes:r:rpl8|RPL8]]|0.404|
|[[:human genes:c:copa|COPA]]|0.403|
|[[:human genes:a:adrm1|ADRM1]]|0.403|
|[[:human genes:g:gid4|GID4]]|0.402|
|[[:human genes:p:pwp2|PWP2]]|0.402|
|[[:human genes:f:fcn2|FCN2]]|0.402|
|[[:human genes:p:prpf3|PRPF3]]|0.401|
|[[:human genes:m:mfap1|MFAP1]]|0.401|
|[[:human genes:p:polr2j3|POLR2J3]]|0.4|
|[[:human genes:d:dhx38|DHX38]]|0.4|
|[[:human genes:u:ubap1|UBAP1]]|0.4|
|[[:human genes:a:aaas|AAAS]]|0.4|
|[[:human genes:b:brd2|BRD2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 625/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|21/28|
|bone|23/26|
|breast|28/33|
|central nervous system|52/56|
|cervix|4/4|
|colorectal|14/17|
|esophagus|10/13|
|fibroblast|0/1|
|gastric|11/16|
|kidney|16/21|
|liver|16/20|
|lung|63/75|
|lymphocyte|13/16|
|ovary|24/26|
|pancreas|21/24|
|peripheral nervous system|14/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|13/22|
|urinary tract|24/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 651
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPS12 Expression in NALM6 Cells: 8.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>