RPS6 [The Human Chemical-Genetic Interaction Map Project]

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======= RPS6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPS6
  * **<color #00a2e8>Official Name</color>**: ribosomal protein S6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6194|6194]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62753|P62753]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPS6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPS6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180460|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S6e|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activation-induced cell death of T cells|
|T cell proliferation involved in immune response|
|mammalian oogenesis stage|
|small ribosomal subunit|
|T cell apoptotic process|
|lymphocyte apoptotic process|
|leukocyte apoptotic process|
|TOR signaling|
|erythrocyte development|
|T cell homeostasis|
|T cell proliferation|
|polysome|
|cytosolic small ribosomal subunit|
|T cell differentiation in thymus|
|lymphocyte homeostasis|
|myeloid cell development|
|T cell activation involved in immune response|
|cytoplasmic ribonucleoprotein granule|
|ribosomal small subunit biogenesis|
|leukocyte homeostasis|
|cell body|
|oogenesis|
|erythrocyte differentiation|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|erythrocyte homeostasis|
|SRP-dependent cotranslational protein targeting to membrane|
|leukocyte proliferation|
|cotranslational protein targeting to membrane|
|myeloid cell homeostasis|
|protein targeting to ER|
|lymphocyte activation involved in immune response|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|viral gene expression|
|female gamete generation|
|T cell differentiation|
|protein localization to endoplasmic reticulum|
|translational initiation|
|placenta development|
|mitotic cell cycle checkpoint|
|ribonucleoprotein complex|
|gastrulation|
|protein targeting to membrane|
|structural constituent of ribosome|
|glucose homeostasis|
|carbohydrate homeostasis|
|cell cycle checkpoint|
|nuclear-transcribed mRNA catabolic process|
|homeostasis of number of cells|
|rRNA processing|
|mRNA catabolic process|
|myeloid cell differentiation|
|rRNA metabolic process|
|T cell activation|
|lymphocyte differentiation|
|RNA catabolic process|
|germ cell development|
|establishment of protein localization to membrane|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|ribosome biogenesis|
|negative regulation of mitotic cell cycle|
|leukocyte differentiation|
|cellular process involved in reproduction in multicellular organism|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|lymphocyte activation|
|ncRNA processing|
|peptide biosynthetic process|
|dendrite|
|reproductive structure development|
|reproductive system development|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|protein kinase binding|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|protein localization to membrane|
|amide biosynthetic process|
|peptide metabolic process|
|cell population proliferation|
|hemopoiesis|
|embryonic morphogenesis|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|hematopoietic or lymphoid organ development|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|developmental process involved in reproduction|
|mitotic cell cycle|
|gamete generation|
|mRNA metabolic process|
|positive regulation of cell death|
|perinuclear region of cytoplasm|
|viral process|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|nucleolus|
|RNA processing|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|cellular macromolecule catabolic process|
|apoptotic process|
|leukocyte activation|
|embryo development|
|intracellular protein transport|
|negative regulation of cell death|
|multi-organism reproductive process|
|cell cycle process|
|endoplasmic reticulum|
|macromolecule catabolic process|
|programmed cell death|
|cell activation|
|cell death|
|immune effector process|
|chemical homeostasis|
|regulation of cell cycle|
|cell cycle|
|RNA binding|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cell development|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.95|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.79|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.73|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.88|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.89|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.07|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.11|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|2.22|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.27|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|2.54|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rps5|RPS5]]|0.448|
|[[:human genes:r:rrp1|RRP1]]|0.427|
|[[:human genes:r:rpl30|RPL30]]|0.418|
|[[:human genes:t:trim52|TRIM52]]|0.41|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.409|
|[[:human genes:r:rps28|RPS28]]|0.408|
|[[:human genes:r:rpl6|RPL6]]|0.407|
|[[:human genes:m:mdm2|MDM2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 738/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 82
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPS6 Expression in NALM6 Cells: 9.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>