RPS7 [The Human Chemical-Genetic Interaction Map Project]

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======= RPS7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPS7
  * **<color #00a2e8>Official Name</color>**: ribosomal protein S7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6201|6201]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62081|P62081]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPS7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPS7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603658|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for rRNA maturation. {ECO:0000269|PubMed:19061985}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S7e|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin ligase inhibitor activity|
|positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|negative regulation of ubiquitin protein ligase activity|
|negative regulation of ubiquitin-protein transferase activity|
|regulation of ubiquitin protein ligase activity|
|positive regulation of signal transduction by p53 class mediator|
|mRNA 5-UTR binding|
|poly(U) RNA binding|
|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|small-subunit processome|
|ribosome|
|cytosolic small ribosomal subunit|
|negative regulation of ubiquitin-dependent protein catabolic process|
|regulation of ubiquitin-protein transferase activity|
|positive regulation of intrinsic apoptotic signaling pathway|
|ribosomal small subunit biogenesis|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of protein ubiquitination|
|mRNA 3-UTR binding|
|negative regulation of protein modification by small protein conjugation or removal|
|negative regulation of cellular protein catabolic process|
|neural tube closure|
|tube closure|
|SRP-dependent cotranslational protein targeting to membrane|
|primary neural tube formation|
|cotranslational protein targeting to membrane|
|neural tube formation|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|embryonic epithelial tube formation|
|viral gene expression|
|epithelial tube formation|
|negative regulation of protein catabolic process|
|protein localization to endoplasmic reticulum|
|translational initiation|
|morphogenesis of embryonic epithelium|
|tube formation|
|regulation of ubiquitin-dependent protein catabolic process|
|ribonucleoprotein complex|
|neural tube development|
|protein targeting to membrane|
|regulation of intrinsic apoptotic signaling pathway|
|structural constituent of ribosome|
|positive regulation of apoptotic signaling pathway|
|protein stabilization|
|regulation of signal transduction by p53 class mediator|
|nuclear-transcribed mRNA catabolic process|
|regulation of protein ubiquitination|
|rRNA processing|
|mRNA catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|rRNA metabolic process|
|regulation of protein modification by small protein conjugation or removal|
|RNA catabolic process|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|establishment of protein localization to membrane|
|synapse|
|negative regulation of transferase activity|
|regulation of protein stability|
|ribosome biogenesis|
|epithelial tube morphogenesis|
|negative regulation of catabolic process|
|negative regulation of proteolysis|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|regulation of protein catabolic process|
|ncRNA processing|
|regulation of apoptotic signaling pathway|
|peptide biosynthetic process|
|focal adhesion|
|morphogenesis of an epithelium|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|protein kinase binding|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|protein localization to membrane|
|centrosome|
|amide biosynthetic process|
|peptide metabolic process|
|tissue morphogenesis|
|embryonic morphogenesis|
|negative regulation of protein modification process|
|protein-containing complex|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|mRNA metabolic process|
|positive regulation of cell death|
|viral process|
|regulation of proteolysis|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|negative regulation of catalytic activity|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|tube development|
|nucleolus|
|RNA processing|
|anatomical structure formation involved in morphogenesis|
|cellular macromolecule catabolic process|
|embryo development|
|regulation of transferase activity|
|regulation of catabolic process|
|intracellular protein transport|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|negative regulation of protein metabolic process|
|epithelium development|
|negative regulation of molecular function|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|tissue development|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|positive regulation of gene expression|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.17|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.75|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.77|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rpl35|RPL35]]|0.522|
|[[:human genes:n:nol10|NOL10]]|0.51|
|[[:human genes:t:twistnb|TWISTNB]]|0.508|
|[[:human genes:r:rps3a|RPS3A]]|0.502|
|[[:human genes:r:rpl6|RPL6]]|0.499|
|[[:human genes:r:rps12|RPS12]]|0.499|
|[[:human genes:c:col2a1|COL2A1]]|0.494|
|[[:human genes:d:ddx56|DDX56]]|0.494|
|[[:human genes:n:nop16|NOP16]]|0.489|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.487|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.484|
|[[:human genes:r:rps11|RPS11]]|0.482|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.479|
|[[:human genes:p:psmb2|PSMB2]]|0.479|
|[[:human genes:n:npipb8|NPIPB8]]|0.478|
|[[:human genes:t:tceb3c|TCEB3C]]|0.477|
|[[:human genes:p:polr2j3|POLR2J3]]|0.476|
|[[:human genes:t:tuba8|TUBA8]]|0.472|
|[[:human genes:i:ik|IK]]|0.469|
|[[:human genes:p:psmb1|PSMB1]]|0.468|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.468|
|[[:human genes:l:lrr1|LRR1]]|0.465|
|[[:human genes:g:golga6b|GOLGA6B]]|0.464|
|[[:human genes:p:psap|PSAP]]|0.463|
|[[:human genes:s:ssh2|SSH2]]|0.462|
|[[:human genes:s:supt6h|SUPT6H]]|0.461|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.459|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.459|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.459|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.459|
|[[:human genes:p:pbxip1|PBXIP1]]|0.458|
|[[:human genes:r:rbbp5|RBBP5]]|0.456|
|[[:human genes:r:rps5|RPS5]]|0.456|
|[[:human genes:p:psmb4|PSMB4]]|0.454|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.454|
|[[:human genes:r:rps27a|RPS27A]]|0.453|
|[[:human genes:c:cbwd3|CBWD3]]|0.452|
|[[:human genes:c:chd4|CHD4]]|0.451|
|[[:human genes:p:pwp2|PWP2]]|0.45|
|[[:human genes:r:rps2|RPS2]]|0.45|
|[[:human genes:r:rps9|RPS9]]|0.45|
|[[:human genes:t:taf1|TAF1]]|0.449|
|[[:human genes:k:kctd17|KCTD17]]|0.448|
|[[:human genes:p:polr1a|POLR1A]]|0.447|
|[[:human genes:b:bysl|BYSL]]|0.446|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.445|
|[[:human genes:v:vasn|VASN]]|0.445|
|[[:human genes:k:krt78|KRT78]]|0.444|
|[[:human genes:p:psma6|PSMA6]]|0.443|
|[[:human genes:a:aatf|AATF]]|0.443|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.443|
|[[:human genes:n:ngdn|NGDN]]|0.442|
|[[:human genes:p:psmd2|PSMD2]]|0.441|
|[[:human genes:s:slc38a7|SLC38A7]]|0.441|
|[[:human genes:f:fbl|FBL]]|0.441|
|[[:human genes:r:rrp7a|RRP7A]]|0.44|
|[[:human genes:e:exosc9|EXOSC9]]|0.44|
|[[:human genes:c:cbwd5|CBWD5]]|0.439|
|[[:human genes:t:timeless|TIMELESS]]|0.439|
|[[:human genes:b:brix1|BRIX1]]|0.439|
|[[:human genes:r:rad51|RAD51]]|0.438|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.437|
|[[:human genes:m:myb|MYB]]|0.436|
|[[:human genes:r:rrn3|RRN3]]|0.436|
|[[:human genes:h:heatr1|HEATR1]]|0.434|
|[[:human genes:s:s1pr4|S1PR4]]|0.434|
|[[:human genes:c:c14orf93|C14orf93]]|0.434|
|[[:human genes:p:psma7|PSMA7]]|0.434|
|[[:human genes:c:ccdc116|CCDC116]]|0.433|
|[[:human genes:a:akt1s1|AKT1S1]]|0.433|
|[[:human genes:r:rps16|RPS16]]|0.433|
|[[:human genes:g:gltscr2|GLTSCR2]]|0.432|
|[[:human genes:r:rps28|RPS28]]|0.43|
|[[:human genes:u:utp20|UTP20]]|0.43|
|[[:human genes:i:isy1|ISY1]]|0.429|
|[[:human genes:m:mfsd12|MFSD12]]|0.428|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.428|
|[[:human genes:r:rpl9|RPL9]]|0.428|
|[[:human genes:a:aamp|AAMP]]|0.428|
|[[:human genes:c:ccna2|CCNA2]]|0.428|
|[[:human genes:p:psmd11|PSMD11]]|0.428|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.427|
|[[:human genes:w:wdr75|WDR75]]|0.427|
|[[:human genes:p:plk1|PLK1]]|0.427|
|[[:human genes:c:cbwd6|CBWD6]]|0.426|
|[[:human genes:t:ticrr|TICRR]]|0.426|
|[[:human genes:p:pola2|POLA2]]|0.426|
|[[:human genes:o:orc1|ORC1]]|0.425|
|[[:human genes:g:golga8j|GOLGA8J]]|0.424|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.423|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.423|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.422|
|[[:human genes:k:krt2|KRT2]]|0.422|
|[[:human genes:u:upf1|UPF1]]|0.421|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.421|
|[[:human genes:m:mki67ip|MKI67IP]]|0.421|
|[[:human genes:m:med17|MED17]]|0.42|
|[[:human genes:a:art5|ART5]]|0.419|
|[[:human genes:k:kpnb1|KPNB1]]|0.418|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.417|
|[[:human genes:c:cdc6|CDC6]]|0.417|
|[[:human genes:s:slc4a1|SLC4A1]]|0.415|
|[[:human genes:g:golga8o|GOLGA8O]]|0.415|
|[[:human genes:c:cdca3|CDCA3]]|0.415|
|[[:human genes:d:disp2|DISP2]]|0.415|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.414|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.413|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.413|
|[[:human genes:u:utp3|UTP3]]|0.413|
|[[:human genes:l:lad1|LAD1]]|0.413|
|[[:human genes:i:igfn1|IGFN1]]|0.412|
|[[:human genes:b:bage|BAGE]]|0.412|
|[[:human genes:b:bage4|BAGE4]]|0.412|
|[[:human genes:b:bage2|BAGE2]]|0.412|
|[[:human genes:t:trim52|TRIM52]]|0.412|
|[[:human genes:b:bage3|BAGE3]]|0.412|
|[[:human genes:a:aqr|AQR]]|0.412|
|[[:human genes:p:pan2|PAN2]]|0.412|
|[[:human genes:p:ppm1d|PPM1D]]|0.412|
|[[:human genes:p:pola1|POLA1]]|0.412|
|[[:human genes:p:prpf3|PRPF3]]|0.412|
|[[:human genes:r:rps21|RPS21]]|0.411|
|[[:human genes:p:ppan|PPAN]]|0.411|
|[[:human genes:c:c3orf17|C3orf17]]|0.411|
|[[:human genes:b:bage5|BAGE5]]|0.411|
|[[:human genes:s:supt5h|SUPT5H]]|0.409|
|[[:human genes:a:adrm1|ADRM1]]|0.409|
|[[:human genes:a:akirin2|AKIRIN2]]|0.407|
|[[:human genes:p:polr2h|POLR2H]]|0.407|
|[[:human genes:p:prim1|PRIM1]]|0.407|
|[[:human genes:f:fcn2|FCN2]]|0.406|
|[[:human genes:h:hivep3|HIVEP3]]|0.406|
|[[:human genes:s:sap30bp|SAP30BP]]|0.405|
|[[:human genes:r:rfxank|RFXANK]]|0.405|
|[[:human genes:s:srfbp1|SRFBP1]]|0.405|
|[[:human genes:e:elmod3|ELMOD3]]|0.404|
|[[:human genes:r:rpl14|RPL14]]|0.404|
|[[:human genes:p:psmd3|PSMD3]]|0.404|
|[[:human genes:n:nol9|NOL9]]|0.404|
|[[:human genes:m:myo18a|MYO18A]]|0.404|
|[[:human genes:c:copg1|COPG1]]|0.404|
|[[:human genes:f:fam160a1|FAM160A1]]|0.403|
|[[:human genes:e:exosc5|EXOSC5]]|0.403|
|[[:human genes:z:znf219|ZNF219]]|0.402|
|[[:human genes:n:nupl1|NUPL1]]|0.402|
|[[:human genes:n:nob1|NOB1]]|0.402|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.402|
|[[:human genes:e:esf1|ESF1]]|0.402|
|[[:human genes:n:ncapg|NCAPG]]|0.401|
|[[:human genes:c:ctage4|CTAGE4]]|0.401|
|[[:human genes:r:ranbp2|RANBP2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 203/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|9/28|
|bone|11/26|
|breast|5/33|
|central nervous system|28/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|2/13|
|fibroblast|1/1|
|gastric|8/16|
|kidney|7/21|
|liver|7/20|
|lung|14/75|
|lymphocyte|4/16|
|ovary|4/26|
|pancreas|0/24|
|peripheral nervous system|3/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|9/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|6/22|
|urinary tract|9/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 880
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPS7 Expression in NALM6 Cells: 8.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>