RRAGA [The Human Chemical-Genetic Interaction Map Project]

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======= RRAGA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RRAGA
  * **<color #00a2e8>Official Name</color>**: Ras related GTP binding A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10670|10670]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7L523|Q7L523]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RRAGA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RRAGA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612194|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:25936802, ECO:0000269|PubMed:8995684, ECO:0000269|PubMed:9394008}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Gtr1 RagA|
|Ras|
|Arf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Gtr1-Gtr2 GTPase complex|
|EGO complex|
|GATOR1 complex|
|positive regulation of cytolysis|
|positive regulation of TORC1 signaling|
|regulation of cytolysis|
|modulation by virus of host morphology or physiology|
|phosphoprotein binding|
|regulation of TORC1 signaling|
|positive regulation of TOR signaling|
|modification by symbiont of host morphology or physiology|
|cellular response to amino acid starvation|
|response to amino acid starvation|
|cellular response to amino acid stimulus|
|negative regulation of autophagy|
|regulation of TOR signaling|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|response to amino acid|
|cell cycle arrest|
|cellular response to starvation|
|modification of morphology or physiology of other organism|
|interaction with host|
|regulation of macroautophagy|
|response to starvation|
|cellular response to acid chemical|
|cellular response to nutrient levels|
|lysosome|
|negative regulation of cellular catabolic process|
|cellular response to extracellular stimulus|
|ubiquitin protein ligase binding|
|lysosomal membrane|
|negative regulation of catabolic process|
|GTPase activity|
|regulation of autophagy|
|cellular response to external stimulus|
|response to acid chemical|
|GTP binding|
|protein heterodimerization activity|
|response to nutrient levels|
|response to extracellular stimulus|
|negative regulation of cell cycle|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|protein ubiquitination|
|viral process|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|protein homodimerization activity|
|apoptotic process|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|cell cycle process|
|response to organonitrogen compound|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cell death|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|cell cycle|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-3.07|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-2.75|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2.55|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.55|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-2.5|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-2.25|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.15|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.82|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.78|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.88|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.88|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.92|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.92|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|2|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.01|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.15|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.18|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.3|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.6|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.77|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lamtor4|LAMTOR4]]|0.645|
|[[:human genes:l:lamtor2|LAMTOR2]]|0.628|
|[[:human genes:f:fnip1|FNIP1]]|0.595|
|[[:human genes:l:lamtor1|LAMTOR1]]|0.564|
|[[:human genes:f:flcn|FLCN]]|0.555|
|[[:human genes:w:wdr24|WDR24]]|0.516|
|[[:human genes:l:lamtor3|LAMTOR3]]|0.496|
|[[:human genes:m:mios|MIOS]]|0.463|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.431|
|[[:human genes:w:wdr59|WDR59]]|0.421|
|[[:human genes:t:tbc1d5|TBC1D5]]|0.416|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 14/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|2/16|
|ovary|1/26|
|pancreas|2/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2916
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RRAGA Expression in NALM6 Cells: 4.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>