RRAGB [The Human Chemical-Genetic Interaction Map Project]

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======= RRAGB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RRAGB
  * **<color #00a2e8>Official Name</color>**: Ras related GTP binding B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10325|10325]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5VZM2|Q5VZM2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RRAGB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RRAGB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300725|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. {ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:9394008}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Gtr1 RagA|
|Arf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|guanyl ribonucleotide binding|
|Gtr1-Gtr2 GTPase complex|
|EGO complex|
|cellular response to leucine starvation|
|positive regulation of TORC1 signaling|
|GTPase binding|
|positive regulation of TOR signaling|
|regulation of TORC1 signaling|
|cellular response to amino acid starvation|
|response to amino acid starvation|
|cellular response to amino acid stimulus|
|regulation of TOR signaling|
|response to amino acid|
|cell cycle arrest|
|cellular response to starvation|
|regulation of macroautophagy|
|response to starvation|
|cellular response to acid chemical|
|cellular response to nutrient levels|
|lysosome|
|cellular response to extracellular stimulus|
|lysosomal membrane|
|GTPase activity|
|regulation of autophagy|
|cellular response to external stimulus|
|response to acid chemical|
|GTP binding|
|protein heterodimerization activity|
|response to nutrient levels|
|response to extracellular stimulus|
|negative regulation of cell cycle|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|regulation of cellular catabolic process|
|regulation of catabolic process|
|cell cycle process|
|response to organonitrogen compound|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|cell cycle|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15590
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RRAGB Expression in NALM6 Cells: 3.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>