RRAGC [The Human Chemical-Genetic Interaction Map Project]

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======= RRAGC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RRAGC
  * **<color #00a2e8>Official Name</color>**: Ras related GTP binding C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64121|64121]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HB90|Q9HB90]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RRAGC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RRAGC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608267|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:27234373}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Gtr1 RagA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Gtr1-Gtr2 GTPase complex|
|EGO complex|
|GTPase binding|
|positive regulation of TOR signaling|
|regulation of TORC1 signaling|
|cellular response to amino acid starvation|
|response to amino acid starvation|
|cellular response to amino acid stimulus|
|GDP binding|
|regulation of TOR signaling|
|response to amino acid|
|cell cycle arrest|
|cellular response to starvation|
|regulation of macroautophagy|
|response to starvation|
|cellular response to acid chemical|
|magnesium ion binding|
|cellular response to nutrient levels|
|lysosome|
|cellular response to extracellular stimulus|
|small GTPase mediated signal transduction|
|GTPase activity|
|regulation of autophagy|
|cellular response to external stimulus|
|response to acid chemical|
|GTP binding|
|RNA splicing|
|protein heterodimerization activity|
|response to nutrient levels|
|response to extracellular stimulus|
|negative regulation of cell cycle|
|cellular response to organonitrogen compound|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|cellular response to nitrogen compound|
|intracellular membrane-bounded organelle|
|regulation of cellular catabolic process|
|RNA processing|
|apoptotic process|
|regulation of catabolic process|
|cell cycle process|
|response to organonitrogen compound|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cell death|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|cell cycle|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|cellular protein localization|
|cellular macromolecule localization|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|intracellular signal transduction|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.98|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.88|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.84|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.79|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|2/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9918
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RRAGC Expression in NALM6 Cells: 4.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>