RRP1 [The Human Chemical-Genetic Interaction Map Project]

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======= RRP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RRP1
  * **<color #00a2e8>Official Name</color>**: ribosomal RNA processing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8568|8568]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56182|P56182]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RRP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RRP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610653|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is the putative homolog of the yeast ribosomal RNA processing protein RRP1. The encoded protein is involved in the late stages of nucleologenesis at the end of mitosis, and may be required for the generation of 28S rRNA. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a critical role in the generation of 28S rRNA.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nop52|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|preribosome, small subunit precursor|
|preribosome, large subunit precursor|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.713|
|[[:human genes:p:polr2j3|POLR2J3]]|0.576|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.497|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.456|
|[[:human genes:a:aamp|AAMP]]|0.452|
|[[:human genes:p:pole|POLE]]|0.446|
|[[:human genes:r:rps12|RPS12]]|0.441|
|[[:human genes:n:nip7|NIP7]]|0.437|
|[[:human genes:c:casc5|CASC5]]|0.434|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.429|
|[[:human genes:r:rpl6|RPL6]]|0.429|
|[[:human genes:r:rps6|RPS6]]|0.427|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.427|
|[[:human genes:d:dtl|DTL]]|0.427|
|[[:human genes:p:psmb4|PSMB4]]|0.424|
|[[:human genes:r:rrp15|RRP15]]|0.423|
|[[:human genes:r:rps2|RPS2]]|0.422|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.42|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.42|
|[[:human genes:r:rpl17|RPL17]]|0.42|
|[[:human genes:t:tceb3c|TCEB3C]]|0.419|
|[[:human genes:c:cope|COPE]]|0.418|
|[[:human genes:a:abhd8|ABHD8]]|0.417|
|[[:human genes:p:pold1|POLD1]]|0.415|
|[[:human genes:p:psma7|PSMA7]]|0.414|
|[[:human genes:p:prpf8|PRPF8]]|0.413|
|[[:human genes:r:rpl34|RPL34]]|0.412|
|[[:human genes:s:supt6h|SUPT6H]]|0.411|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.408|
|[[:human genes:p:psmd3|PSMD3]]|0.407|
|[[:human genes:n:nup98|NUP98]]|0.406|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.405|
|[[:human genes:c:cdca3|CDCA3]]|0.405|
|[[:human genes:r:rpl30|RPL30]]|0.401|
|[[:human genes:r:rpl38|RPL38]]|0.4|
|[[:human genes:d:ddtl|DDTL]]|0.4|
|[[:human genes:n:nsf|NSF]]|0.4|
|[[:human genes:c:cactin|CACTIN]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 155/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|5/28|
|blood|1/28|
|bone|7/26|
|breast|4/33|
|central nervous system|17/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|11/21|
|liver|3/20|
|lung|8/75|
|lymphocyte|4/16|
|ovary|5/26|
|pancreas|6/24|
|peripheral nervous system|4/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|6/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|7/22|
|urinary tract|3/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 588
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RRP1 Expression in NALM6 Cells: 6.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>