RSPO3 [The Human Chemical-Genetic Interaction Map Project]

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======= RSPO3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RSPO3
  * **<color #00a2e8>Official Name</color>**: R-spondin 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84870|84870]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BXY4|Q9BXY4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RSPO3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RSPO3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610574|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta- catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity). {ECO:0000250|UniProtKB:Q2TJ95, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22615920}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TSP 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of Wnt signaling pathway, planar cell polarity pathway|
|branching involved in labyrinthine layer morphogenesis|
|positive regulation of non-canonical Wnt signaling pathway|
|regulation of Wnt signaling pathway, planar cell polarity pathway|
|labyrinthine layer morphogenesis|
|regulation of non-canonical Wnt signaling pathway|
|embryonic placenta morphogenesis|
|blood vessel remodeling|
|frizzled binding|
|labyrinthine layer development|
|sprouting angiogenesis|
|embryonic placenta development|
|tissue remodeling|
|regulation of establishment of planar polarity|
|positive regulation of canonical Wnt signaling pathway|
|placenta development|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|heparin binding|
|positive regulation of Wnt signaling pathway|
|regulation of morphogenesis of an epithelium|
|regulation of animal organ morphogenesis|
|regulation of canonical Wnt signaling pathway|
|angiogenesis|
|signaling receptor binding|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|in utero embryonic development|
|blood vessel morphogenesis|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|embryo development|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|cell-cell signaling|
|reproductive process|
|reproduction|
|extracellular space|
|positive regulation of signal transduction|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.83|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.74|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.73|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|1.83|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|2.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18750
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RSPO3 Expression in NALM6 Cells: -4.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>