RTFDC1 [The Human Chemical-Genetic Interaction Map Project]

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======= RTFDC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RTF2
  * **<color #00a2e8>Official Name</color>**: replication termination factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51507|51507]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BY42|Q9BY42]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RTFDC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RTFDC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rtf2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|site-specific DNA replication termination|
|genetic imprinting at mating-type locus|
|cell cycle DNA replication termination|
|mitotic DNA replication termination|
|DNA replication termination|
|nuclear DNA replication termination|
|establishment of imprinting at mating-type locus|
|site-specific DNA replication termination at RTS1 barrier|
|regulation of mating type switching|
|regulation of DNA stability|
|mitotic DNA replication|
|cellular response to hydroxyurea|
|response to hydroxyurea|
|response to antimetabolite|
|genetic imprinting|
|replication fork|
|regulation of cell fate commitment|
|nuclear DNA replication|
|cell cycle DNA replication|
|response to antineoplastic agent|
|DNA-dependent DNA replication|
|regulation of reproductive process|
|DNA replication|
|cellular response to inorganic substance|
|cellular response to drug|
|response to inorganic substance|
|mitotic cell cycle process|
|cellular response to nitrogen compound|
|mitotic cell cycle|
|DNA metabolic process|
|molecular function|
|cell cycle process|
|response to drug|
|response to nitrogen compound|
|cell cycle|
|DNA binding|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.76|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.15|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.85|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.83|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.81|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-1.76|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.76|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.75|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.7|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 143/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|10/28|
|bone|7/26|
|breast|5/33|
|central nervous system|17/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|4/20|
|lung|16/75|
|lymphocyte|4/16|
|ovary|5/26|
|pancreas|3/24|
|peripheral nervous system|4/16|
|plasma cell|7/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|6/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1105
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RTFDC1 Expression in NALM6 Cells: 5.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>