RUNX3 [The Human Chemical-Genetic Interaction Map Project]

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======= RUNX3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RUNX3
  * **<color #00a2e8>Official Name</color>**: RUNX family transcription factor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=864|864]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13761|Q13761]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RUNX3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RUNX3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600210|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). {ECO:0000269|PubMed:20599712}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RunxI|
|Runt|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|core-binding factor complex|
|positive regulation of CD8-positive, alpha-beta T cell differentiation|
|positive regulation of CD8-positive, alpha-beta T cell activation|
|regulation of CD8-positive, alpha-beta T cell differentiation|
|peripheral nervous system neuron development|
|peripheral nervous system neuron differentiation|
|regulation of CD8-positive, alpha-beta T cell activation|
|negative regulation of CD4-positive, alpha-beta T cell differentiation|
|negative regulation of alpha-beta T cell differentiation|
|negative regulation of CD4-positive, alpha-beta T cell activation|
|negative regulation of alpha-beta T cell activation|
|negative regulation of T cell differentiation|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of alpha-beta T cell differentiation|
|negative regulation of lymphocyte differentiation|
|positive regulation of alpha-beta T cell activation|
|regulation of CD4-positive, alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|peripheral nervous system development|
|positive regulation of T cell differentiation|
|chondrocyte differentiation|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|negative regulation of leukocyte differentiation|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|negative regulation of epithelial cell proliferation|
|negative regulation of hemopoiesis|
|regulation of T cell differentiation|
|negative regulation of lymphocyte activation|
|positive regulation of leukocyte differentiation|
|response to transforming growth factor beta|
|regulation of lymphocyte differentiation|
|cartilage development|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|positive regulation of hemopoiesis|
|negative regulation of cell activation|
|positive regulation of T cell activation|
|positive regulation of leukocyte cell-cell adhesion|
|connective tissue development|
|nuclear chromatin|
|positive regulation of cell-cell adhesion|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|regulation of leukocyte cell-cell adhesion|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|regulation of T cell activation|
|regulation of epithelial cell proliferation|
|positive regulation of lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|transcription by RNA polymerase II|
|skeletal system development|
|regulation of lymphocyte activation|
|response to growth factor|
|hemopoiesis|
|negative regulation of cell cycle|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|transcription, DNA-templated|
|regulation of cell activation|
|nucleic acid-templated transcription|
|immune system development|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|intracellular membrane-bounded organelle|
|negative regulation of cell differentiation|
|neuron development|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|protein phosphorylation|
|neuron differentiation|
|nucleobase-containing compound biosynthetic process|
|positive regulation of immune system process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp187|proTAME 5μM R04 exp187]]|-2.33|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.92|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.76|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.72|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.83|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8470
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RUNX3 Expression in NALM6 Cells: 1.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>