RXFP2 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= RXFP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RXFP2
  * **<color #00a2e8>Official Name</color>**: relaxin family peptide receptor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=122042|122042]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WXD0|Q8WXD0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RXFP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RXFP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606655|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|Ldl recept a|
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein-hormone receptor activity|
|oocyte maturation|
|positive regulation of cAMP-mediated signaling|
|oocyte development|
|activation of adenylate cyclase activity|
|G protein-coupled peptide receptor activity|
|peptide hormone binding|
|oocyte differentiation|
|regulation of cAMP-mediated signaling|
|oogenesis|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|female gamete generation|
|male gonad development|
|development of primary male sexual characteristics|
|anatomical structure maturation|
|cAMP-mediated signaling|
|male sex differentiation|
|cell maturation|
|hormone-mediated signaling pathway|
|cyclic-nucleotide-mediated signaling|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|gonad development|
|development of primary sexual characteristics|
|developmental maturation|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|germ cell development|
|sex differentiation|
|second-messenger-mediated signaling|
|cellular process involved in reproduction in multicellular organism|
|reproductive structure development|
|reproductive system development|
|cellular response to hormone stimulus|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|multi-organism reproductive process|
|negative regulation of cell death|
|positive regulation of intracellular signal transduction|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.59|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.09|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-1.93|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.86|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-1.84|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.84|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.82|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.79|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-1.76|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.72|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.72|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.77|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.82|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.86|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|2.18|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.19|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|2.23|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.25|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.31|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.46|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|2.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9512
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RXFP2 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>