RYR3 [The Human Chemical-Genetic Interaction Map Project]

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======= RYR3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RYR3
  * **<color #00a2e8>Official Name</color>**: ryanodine receptor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6263|6263]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15413|Q15413]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RYR3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RYR3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180903|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes. For example, the encoded protein is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by depolarization of T-tubules. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling. {ECO:0000250, ECO:0000269|PubMed:12354756}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MIR|
|RIH assoc|
|Ion trans|
|RyR|
|RYDR ITPR|
|SPRY|
|RR TM4-6|
|Ins145 P3 rec|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium-induced calcium release activity|
|ryanodine-sensitive calcium-release channel activity|
|cellular response to magnesium ion|
|cellular response to caffeine|
|negative regulation of cytosolic calcium ion concentration|
|calcium-release channel activity|
|cellular response to purine-containing compound|
|response to diuretic|
|response to caffeine|
|cellular response to ATP|
|response to magnesium ion|
|calcium channel complex|
|smooth endoplasmic reticulum|
|sarcoplasmic reticulum membrane|
|response to ATP|
|cellular response to alkaloid|
|sarcoplasmic reticulum|
|release of sequestered calcium ion into cytosol|
|negative regulation of sequestering of calcium ion|
|calcium ion transmembrane import into cytosol|
|cellular response to nutrient|
|regulation of cardiac conduction|
|calcium ion transport into cytosol|
|cellular response to calcium ion|
|cytosolic calcium ion transport|
|protein homotetramerization|
|sarcolemma|
|response to alkaloid|
|regulation of sequestering of calcium ion|
|Z disc|
|response to organophosphorus|
|cytoplasmic vesicle membrane|
|protein tetramerization|
|response to calcium ion|
|response to purine-containing compound|
|cellular response to xenobiotic stimulus|
|cellular response to metal ion|
|calcium ion transmembrane transport|
|calmodulin binding|
|response to nutrient|
|cellular response to inorganic substance|
|cellular response to nutrient levels|
|regulation of heart contraction|
|calcium ion transport|
|cellular response to extracellular stimulus|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|divalent metal ion transport|
|response to xenobiotic stimulus|
|divalent inorganic cation transport|
|regulation of cytosolic calcium ion concentration|
|cellular response to external stimulus|
|protein homooligomerization|
|response to metal ion|
|cellular response to drug|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|response to nutrient levels|
|protein complex oligomerization|
|response to extracellular stimulus|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of system process|
|cellular response to organonitrogen compound|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|perinuclear region of cytoplasm|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|response to organic cyclic compound|
|ion transmembrane transport|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|homeostatic process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.86|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.72|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4062
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RYR3 Expression in NALM6 Cells: 3.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>