S100A12 [The Human Chemical-Genetic Interaction Map Project]

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======= S100A12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: S100A12
  * **<color #00a2e8>Official Name</color>**: S100 calcium binding protein A12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6283|6283]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P80511|P80511]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=S100A12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20S100A12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603112|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus. {ECO:0000269|PubMed:11522286, ECO:0000269|PubMed:17208591, ECO:0000269|PubMed:18292089, ECO:0000269|PubMed:19386136}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|S 100|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RAGE receptor binding|
|mast cell activation|
|defense response to fungus|
|monocyte chemotaxis|
|mononuclear cell migration|
|cytokine secretion|
|response to fungus|
|disruption of cells of other organism|
|killing of cells of other organism|
|copper ion binding|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|neutrophil chemotaxis|
|granulocyte chemotaxis|
|cell killing|
|neutrophil migration|
|granulocyte migration|
|antimicrobial humoral response|
|secretory granule lumen|
|myeloid leukocyte migration|
|xenobiotic metabolic process|
|positive regulation of inflammatory response|
|leukocyte chemotaxis|
|cytokine production|
|positive regulation of NF-kappaB transcription factor activity|
|modification of morphology or physiology of other organism|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|peptide secretion|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|cellular response to xenobiotic stimulus|
|cell chemotaxis|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of MAP kinase activity|
|response to xenobiotic stimulus|
|defense response to bacterium|
|regulation of inflammatory response|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|humoral immune response|
|cytoskeleton|
|leukocyte migration|
|regulation of DNA-binding transcription factor activity|
|positive regulation of defense response|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|inflammatory response|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|positive regulation of response to external stimulus|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|positive regulation of transferase activity|
|response to bacterium|
|regulated exocytosis|
|calcium ion binding|
|regulation of MAPK cascade|
|regulation of defense response|
|innate immune response|
|leukocyte mediated immunity|
|exocytosis|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|zinc ion binding|
|regulation of kinase activity|
|leukocyte activation|
|defense response to other organism|
|cell migration|
|regulation of transferase activity|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|export from cell|
|positive regulation of phosphorylation|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|regulation of response to external stimulus|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|protein transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|nitrogen compound transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15756
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='S100A12 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>