SAMD1 [The Human Chemical-Genetic Interaction Map Project]

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======= SAMD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SAMD1
  * **<color #00a2e8>Official Name</color>**: sterile alpha motif domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=90378|90378]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6SPF0|Q6SPF0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SAMD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SAMD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620206|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in atherogenesis by immobilizing LDL in the atherial wall. {ECO:0000269|PubMed:16159594}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.72|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.72|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.74|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.86|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.89|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.91|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.91|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.11|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.34|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.68|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.7|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.73|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.96|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|3.46|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|3.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tfip11|TFIP11]]|0.461|
|[[:human genes:g:gosr2|GOSR2]]|0.452|
|[[:human genes:o:orc6|ORC6]]|0.437|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.417|
|[[:human genes:v:vps54|VPS54]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2491
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SAMD1 Expression in NALM6 Cells: 5.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>