SAR1A [The Human Chemical-Genetic Interaction Map Project]

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======= SAR1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SAR1A
  * **<color #00a2e8>Official Name</color>**: secretion associated Ras related GTPase 1A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56681|56681]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NR31|Q9NR31]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SAR1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SAR1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607691|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES). {ECO:0000250, ECO:0000269|PubMed:17005010}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|G-alpha|
|Miro|
|Arf|
|SRPRB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis|
|regulation of COPII vesicle coating|
|regulation of vesicle targeting, to, from or within Golgi|
|COPII-coated vesicle cargo loading|
|positive regulation of protein exit from endoplasmic reticulum|
|COPII vesicle coat|
|regulation of ER to Golgi vesicle-mediated transport|
|vesicle cargo loading|
|regulation of protein exit from endoplasmic reticulum|
|endoplasmic reticulum exit site|
|COPII-coated vesicle budding|
|Golgi vesicle budding|
|localization within membrane|
|vesicle budding from membrane|
|positive regulation of intracellular protein transport|
|positive regulation of intracellular transport|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|regulation of intracellular protein transport|
|vesicle organization|
|positive regulation of cellular protein localization|
|GTPase activity|
|regulation of intracellular transport|
|Golgi vesicle transport|
|GTP binding|
|positive regulation of protein transport|
|regulation of protein complex assembly|
|positive regulation of establishment of protein localization|
|regulation of cellular protein localization|
|regulation of vesicle-mediated transport|
|Golgi membrane|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|membrane organization|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|intracellular protein transport|
|endoplasmic reticulum|
|regulation of protein localization|
|regulation of organelle organization|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.93|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.91|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.87|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.7|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.7|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.98|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.01|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.09|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.43|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.77|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.86|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|4.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:sec23b|SEC23B]]|0.561|
|[[:human genes:s:sec31a|SEC31A]]|0.553|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16754
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SAR1A Expression in NALM6 Cells: 7.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>