SBNO1 [The Human Chemical-Genetic Interaction Map Project]

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======= SBNO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SBNO1
  * **<color #00a2e8>Official Name</color>**: strawberry notch homolog 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55206|55206]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A3KN83|A3KN83]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SBNO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SBNO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614274|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ResIII|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular component|
|molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.22|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-2.08|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.05|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.99|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.96|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.9|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.89|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.88|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.88|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.88|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.75|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.73|
|[[:results:exp132|Metformin 40μM R03 exp132]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:chmp4b|CHMP4B]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 710/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|27/28|
|bone|25/26|
|breast|31/33|
|central nervous system|52/56|
|cervix|3/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|71/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|13/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|28/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 785
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SBNO1 Expression in NALM6 Cells: 7.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>