SCAF4 [The Human Chemical-Genetic Interaction Map Project]

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======= SCAF4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCAF4
  * **<color #00a2e8>Official Name</color>**: SR-related CTD associated factor 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57466|57466]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95104|O95104]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCAF4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCAF4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616023|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene likely encodes a member of the arginine/serine-rich splicing factor family. A similar protein in Rat appears to bind the large subunit of RNA polymerase II and provide a link between transcription and pre-mRNA splicing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May act to physically and functionally link transcription and pre-mRNA processing. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
|DUF618|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of termination of RNA polymerase II transcription|
|negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled|
|negative regulation of DNA-templated transcription, termination|
|regulation of termination of RNA polymerase II transcription, poly(A)-coupled|
|regulation of termination of RNA polymerase II transcription|
|RNA polymerase II C-terminal domain phosphoserine binding|
|regulation of DNA-templated transcription, termination|
|negative regulation of protein complex disassembly|
|regulation of protein complex disassembly|
|negative regulation of cellular component organization|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.71|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.93|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.94|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.04|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.05|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.13|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.19|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.22|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2666
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCAF4 Expression in NALM6 Cells: 6.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>