SCD [The Human Chemical-Genetic Interaction Map Project]

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======= SCD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCD
  * **<color #00a2e8>Official Name</color>**: stearoyl-CoA desaturase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6319|6319]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00767|O00767]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604031|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FA desaturase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|palmitoyl-CoA 9-desaturase activity|
|monounsaturated fatty acid biosynthetic process|
|stearoyl-CoA 9-desaturase activity|
|monounsaturated fatty acid metabolic process|
|fatty-acyl-CoA biosynthetic process|
|fatty-acyl-CoA metabolic process|
|unsaturated fatty acid biosynthetic process|
|regulation of cholesterol biosynthetic process|
|regulation of sterol biosynthetic process|
|thioester biosynthetic process|
|acyl-CoA biosynthetic process|
|regulation of cholesterol metabolic process|
|nucleoside bisphosphate biosynthetic process|
|purine nucleoside bisphosphate biosynthetic process|
|ribonucleoside bisphosphate biosynthetic process|
|regulation of alcohol biosynthetic process|
|response to fatty acid|
|regulation of steroid biosynthetic process|
|fatty acid derivative biosynthetic process|
|acyl-CoA metabolic process|
|thioester metabolic process|
|positive regulation of cold-induced thermogenesis|
|integral component of endoplasmic reticulum membrane|
|unsaturated fatty acid metabolic process|
|regulation of steroid metabolic process|
|fatty acid biosynthetic process|
|oxidoreductase activity|
|ribonucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|iron ion binding|
|coenzyme biosynthetic process|
|regulation of cold-induced thermogenesis|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|fatty acid derivative metabolic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|sulfur compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|regulation of lipid biosynthetic process|
|cofactor biosynthetic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|purine ribonucleotide metabolic process|
|fatty acid metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|response to acid chemical|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|amide biosynthetic process|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|cellular amide metabolic process|
|response to lipid|
|nucleolus|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|endoplasmic reticulum|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|response to oxygen-containing compound|
|cellular nitrogen compound biosynthetic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-2.93|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.77|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-2.15|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-2.11|
|[[:results:exp519|RS-1 10μM R08 exp519]]|-2.03|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.03|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.91|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.86|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.79|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-1.77|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.72|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.74|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.81|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.87|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.56|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|2.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 125/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|8/28|
|bone|1/26|
|breast|4/33|
|central nervous system|4/56|
|cervix|1/4|
|colorectal|6/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|5/21|
|liver|2/20|
|lung|16/75|
|lymphocyte|3/16|
|ovary|2/26|
|pancreas|6/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|6/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|7/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4785
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCD Expression in NALM6 Cells: 9.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>