SCT [The Human Chemical-Genetic Interaction Map Project]

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======= SCT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCT
  * **<color #00a2e8>Official Name</color>**: secretin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6343|6343]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09683|P09683]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182099|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hormone 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of pancreatic juice secretion|
|negative regulation of gastrin-induced gastric acid secretion|
|regulation of gastrin-induced gastric acid secretion|
|digestive hormone activity|
|positive regulation of somatostatin secretion|
|regulation of somatostatin secretion|
|cellular water homeostasis|
|regulation of pancreatic juice secretion|
|pancreatic juice secretion|
|negative regulation of gastric acid secretion|
|positive regulation of digestive system process|
|regulation of gastric acid secretion|
|diet induced thermogenesis|
|negative regulation of digestive system process|
|adaptive thermogenesis|
|secretion by tissue|
|positive regulation of cAMP-mediated signaling|
|regulation of appetite|
|positive regulation of lipid catabolic process|
|response to dietary excess|
|cell volume homeostasis|
|embryonic digestive tract development|
|regulation of digestive system process|
|regulation of cAMP-mediated signaling|
|regulation of lipid catabolic process|
|G protein-coupled receptor binding|
|water homeostasis|
|digestive system process|
|body fluid secretion|
|cell|
|hippocampus development|
|positive regulation of peptide hormone secretion|
|hormone activity|
|protein N-terminus binding|
|limbic system development|
|digestion|
|positive regulation of hormone secretion|
|digestive tract development|
|positive regulation of lipid metabolic process|
|digestive system development|
|pallium development|
|regulation of cell size|
|regulation of synaptic plasticity|
|regulation of peptide hormone secretion|
|negative regulation of secretion|
|telencephalon development|
|regulation of hormone secretion|
|positive regulation of peptide secretion|
|signaling receptor binding|
|regulation of cellular component size|
|forebrain development|
|regulation of lipid metabolic process|
|positive regulation of secretion by cell|
|positive regulation of catabolic process|
|embryonic organ development|
|positive regulation of secretion|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|cellular component|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of body fluid levels|
|response to nutrient levels|
|regulation of anatomical structure size|
|response to extracellular stimulus|
|regulation of hormone levels|
|regulation of system process|
|regulation of peptide transport|
|brain development|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|head development|
|regulation of secretion|
|tube development|
|cellular homeostasis|
|embryo development|
|central nervous system development|
|positive regulation of transport|
|regulation of catabolic process|
|positive regulation of intracellular signal transduction|
|chemical homeostasis|
|secretion|
|negative regulation of multicellular organismal process|
|G protein-coupled receptor signaling pathway|
|extracellular space|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7977
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCT Expression in NALM6 Cells: -2.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>