SCXB [The Human Chemical-Genetic Interaction Map Project]

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======= SCXB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCX
  * **<color #00a2e8>Official Name</color>**: scleraxis bHLH transcription factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=642658|642658]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7RTU7|Q7RTU7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCXB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCXB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609067|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tendon formation|
|deltoid tuberosity development|
|tendon cell differentiation|
|sclerotome development|
|tendon development|
|positive regulation of gastrulation|
|heart valve formation|
|Sertoli cell differentiation|
|positive regulation of collagen biosynthetic process|
|bHLH transcription factor binding|
|positive regulation of collagen metabolic process|
|replacement ossification|
|endochondral ossification|
|face morphogenesis|
|positive regulation of cartilage development|
|regulation of collagen biosynthetic process|
|head morphogenesis|
|regulation of gastrulation|
|positive regulation of embryonic development|
|regulation of collagen metabolic process|
|body morphogenesis|
|collagen fibril organization|
|face development|
|E-box binding|
|skeletal muscle cell differentiation|
|heart valve morphogenesis|
|heart valve development|
|mesoderm formation|
|mesoderm morphogenesis|
|regulation of cartilage development|
|endochondral bone morphogenesis|
|cellular response to mechanical stimulus|
|chondrocyte differentiation|
|somite development|
|BMP signaling pathway|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|response to BMP|
|cellular response to BMP stimulus|
|formation of primary germ layer|
|bone morphogenesis|
|skeletal muscle tissue development|
|mesoderm development|
|embryonic skeletal system development|
|regulation of embryonic development|
|skeletal muscle organ development|
|male gonad development|
|development of primary male sexual characteristics|
|cellular response to transforming growth factor beta stimulus|
|male sex differentiation|
|gastrulation|
|response to transforming growth factor beta|
|cartilage development|
|appendage development|
|limb development|
|tissue homeostasis|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|bone development|
|transcription factor complex|
|gonad development|
|response to mechanical stimulus|
|development of primary sexual characteristics|
|mesenchyme development|
|connective tissue development|
|skeletal system morphogenesis|
|ossification|
|sex differentiation|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|multicellular organismal homeostasis|
|cellular response to external stimulus|
|extracellular matrix organization|
|anatomical structure homeostasis|
|extracellular structure organization|
|sequence-specific DNA binding|
|reproductive structure development|
|reproductive system development|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|supramolecular fiber organization|
|muscle structure development|
|protein heterodimerization activity|
|skeletal system development|
|cellular response to growth factor stimulus|
|heart development|
|response to growth factor|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|developmental process involved in reproduction|
|epithelial cell differentiation|
|enzyme linked receptor protein signaling pathway|
|head development|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|animal organ morphogenesis|
|embryo development|
|negative regulation of cell death|
|regulation of anatomical structure morphogenesis|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11484
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCXB Expression in NALM6 Cells: -1.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>